Evidence map›Paper›PMID 30882007›Full record

ReviewJournal of immunology research2019

Memory NK Cell Features Exploitable in Anticancer Immunotherapy.

Cristina Capuano, Chiara Pighi, Simone Battella, Angela Santoni, Gabriella Palmieri, Ricciarda Galandrini

Abstract readReview
In one paragraph

Review in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  13. Engineering Targeting Materials for Therapeutic Cancer Vaccines.Frontiers in bioengineering and biotechnology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cristina CapuanoDepartment of Experimental Medicine, Sapienza University of Rome, Rome 00161, Italy.
Chiara PighiDepartment of Experimental Medicine, Sapienza University of Rome, Rome 00161, Italy.
Simone BattellaDepartment of Experimental Medicine, Sapienza University of Rome, Rome 00161, Italy.
Angela SantoniDepartment of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy.
Gabriella PalmieriDepartment of Experimental Medicine, Sapienza University of Rome, Rome 00161, Italy.
Ricciarda GalandriniDepartment of Experimental Medicine, Sapienza University of Rome, Rome 00161, Italy.ORCID 0000-0003-2660-1456

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived, hyperfunctional populations, dubbed memory or memory-like NK cells. Despite significant progress in the field of NK cell-based immunotherapies, some factors including their short life span and the occurrence of a tumor-dependent functional exhaustion have limited their clinical efficacy so that strategies aimed at overcoming these limitations represent one of the main current challenges in the field. In this scenario, the exploitation of NK cell memory may have a considerable potential. This article summarizes recent evidence in the literature on the peculiar features that render memory NK cells an attractive tool for antitumor immunotherapy, including their long-term survival and

Indexed as

Immunologic MemoryAnimalsAntibodies, MonoclonalCytokinesHumansImmunotherapy, AdoptiveKiller Cells, NaturalLymphocyte ActivationMiceNeoplasmsAntibodies, MonoclonalCytokines

Identifiers

PMID30882007
PMCPMC6381560

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.