ArticleChemical science2019
A tandem dearomatization/rearomatization strategy: enantioselective N-heterocyclic carbene-catalyzed α-arylation.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Mol-SGGI: an attention-guided comprehensive molecular multi-representation learning and adaptive fusion framework for molecular property prediction.Molecular diversity · 2026Article
- Enantioselective aza-electrophilic dearomatization of naphthalene derivatives.Nature communications · 2025Article
- Enantioselective construction of triaryl-substituted all-carbon quaternary stereocentersChemical science · 2023Article
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Authors and funding
2 authors.
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Abstract
In this study, the first example of the carbene-catalyzed tandem dearomatization/rearomatization reaction of azonaphthalenes with α-chloroaldehydes is described. This protocol enables the efficient assembly of chiral dihydrocinnolinone derivatives in good yields with excellent enantioselectivities (up to 99% ee). Moreover, this strategy enables not only the highly enantioselective NHC-catalyzed nucleophilic aromatic substitution, but also a formal Csp
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