Evidence map›Paper›PMID 30881678›Full record

ArticleChemical science2019

Selective recognition of choline phosphate by tripodal hexa-urea receptors with dual binding sites: crystal and solution evidence.

Wei Zuo, Chuandong Jia, Huizheng Zhang, Yanxia Zhao, Xiao-Juan Yang, Biao Wu

Abstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei ZuoKey Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education , College of Chemistry and Materials Science , Northwest University , Xi'an 710069 , China . Email: yangxiaojuan@nwu.edu.cn ; Email: wubiao@nwu.edu.cn.
Chuandong JiaKey Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education , College of Chemistry and Materials Science , Northwest University , Xi'an 710069 , China . Email: yangxiaojuan@nwu.edu.cn ; Email: wubiao@nwu.edu.cn.
Huizheng ZhangKey Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education , College of Chemistry and Materials Science , Northwest University , Xi'an 710069 , China . Email: yangxiaojuan@nwu.edu.cn ; Email: wubiao@nwu.edu.cn.
Yanxia ZhaoKey Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education , College of Chemistry and Materials Science , Northwest University , Xi'an 710069 , China . Email: yangxiaojuan@nwu.edu.cn ; Email: wubiao@nwu.edu.cn.
Xiao-Juan YangKey Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education , College of Chemistry and Materials Science , Northwest University , Xi'an 710069 , China . Email: yangxiaojuan@nwu.edu.cn ; Email: wubiao@nwu.edu.cn.ORCID 0000-0002-0869-4460
Biao WuKey Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education , College of Chemistry and Materials Science , Northwest University , Xi'an 710069 , China . Email: yangxiaojuan@nwu.edu.cn ; Email: wubiao@nwu.edu.cn.ORCID 0000-0002-0724-4150

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two tripodal hexa-urea receptors functionalized with aromatic terminal groups are capable of binding choline phosphate (CP). Crystal structures of the host-guest complexes reveal that the zwitterion CP is efficiently encapsulated in the tripodal hosts in a dual-site binding mode. The phosphate tail of CP is coordinated by the urea groups and the quaternary ammonium head is bound in a 'composite aromatic box' through cation-π and hydrogen-bonding interactions. Such a partial aromatic binding environment for the Me

Identifiers

PMID30881678
PMCPMC6385852

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.