Evidence map›Paper›PMID 30881672›Full record

ArticleChemical science2019

Building blocks for recognition-encoded oligoesters that form H-bonded duplexes.

Filip T Szczypiński, Christopher A Hunter

Abstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Recognition-Encoded Molecules: A Minimal Self-Replicator.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  3. Article
  4. Article
  5. Synthetically encoded complementary oligomers.Nature reviews. Chemistry · 2023
    Review
  6. Article
  7. Article
  8. Recognition-Encoded Synthetic Information Molecules.Accounts of chemical research · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Filip T SzczypińskiDepartment of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email: herchelsmith.orgchem@ch.cam.ac.uk.ORCID 0000-0003-3174-8532
Christopher A HunterDepartment of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email: herchelsmith.orgchem@ch.cam.ac.uk.ORCID 0000-0002-5182-1859

Funding

European Research Council 320539
6 · The paper itself

Abstract

Competition from intramolecular folding is a major challenge in the design of synthetic oligomers that form intermolecular duplexes in a sequence-selective manner. One strategy is to use very rigid backbones that prevent folding, but this design can prejudice duplex formation if the geometry is not exactly right. The alternative approach found in nucleic acids is to use bases (or recognition units) that have different dimensions. A long-short base-pairing scheme makes folding geometrically difficult and is compatible with the flexible backbones that are required to guarantee duplex formation. A monomer building block equipped with a long hydrogen bond donor (phenol,

Identifiers

PMID30881672
PMCPMC6385898

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.