Evidence map›Paper›PMID 30881667›Full record

ArticleChemical science2019

Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the

Shi-Hui Dong, Alexey Kulikovsky, Inna Zukher, Paola Estrada, Svetlana Dubiley, Konstantin Severinov, Satish K Nair

Abstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Late-Stage Posttranslational Assembly of Fosfazinomycins.bioRxiv : the preprint server for biology · 2026
    Article
  2. Myxarylin: TotalJournal of the American Chemical Society · 2026
    Article
  3. Article
  4. ThiF-Like Enzyme Chemistry in Primary and Secondary Metabolism.Chembiochem : a European journal of chemical biology · 2025
    Review
  5. Article
  6. Review
  7. Indolylamide Macrocyclization by aOrganic letters · 2025
    Article
  8. Trojan horse peptide conjugates remodel the activity spectrum of clinical antibiotics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shi-Hui DongDepartment of Biochemistry , University of Illinois at Urbana-Champaign , Illinois , USA . Email: snair@illinois.edu.ORCID 0000-0002-1743-2163
Alexey KulikovskyDepartment of Biochemistry , University of Illinois at Urbana-Champaign , Illinois , USA . Email: snair@illinois.edu.
Inna ZukherInstitute of Gene Biology , Russian Academy of Science , 34/5 Vavilo str. , 11934 Moscow , Russia.ORCID 0000-0003-0368-1676
Paola EstradaDepartment of Biochemistry , University of Illinois at Urbana-Champaign , Illinois , USA . Email: snair@illinois.edu.
Svetlana DubileyInstitute of Gene Biology , Russian Academy of Science , 34/5 Vavilo str. , 11934 Moscow , Russia.ORCID 0000-0001-9225-5534
Konstantin SeverinovInstitute of Gene Biology , Russian Academy of Science , 34/5 Vavilo str. , 11934 Moscow , Russia.
Satish K NairDepartment of Biochemistry , University of Illinois at Urbana-Champaign , Illinois , USA . Email: snair@illinois.edu.ORCID 0000-0003-1790-1334

Funding

Exploring Peptide Conjugates as Trojan Horse Systems for Drug Design and DiscoveryR01AI117210 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI NAIR, SATISH K · 2016 to 2020
$2.2M
Exploring Peptide Conjugates as Trojan Horse Systems for Drug Design and Discovery.R56AI117210 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI NAIR, SATISH K · 2015 to 2015
$467k
NIAID NIH HHS R01 AI117210NIAID NIH HHS R56 AI117210
6 · The paper itself

Abstract

Microcin C7 (McC) is a peptide antibiotic modified by a linkage of the terminal isoAsn amide to AMP

Identifiers

PMID30881667
PMCPMC6385645

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.