ArticleChemical science2019
Exploration of solid-state nanopores in characterizing reaction mixtures generated from a catalytic DNA assembly circuit.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Biosensing With Nanofluidics.Exploration (Beijing, China) · 2026Review
- DNA Volume, Topology, and Flexibility Dictate Nanopore Current Signals.Nano letters · 2023Article
- Multiplexed Nanopore-Based Nucleic Acid Sensing and Bacterial Identification Using DNA Dumbbell Nanoswitches.Journal of the American Chemical Society · 2023Article
- Monitoring and modulating a catalytic hybridization circuit for self-adaptive bioorthogonal DNA assembly.Chemical science · 2022Article
- A nanopore interface for higher bandwidth DNA computing.Nature communications · 2022Article
- Structure-flexible DNA origami translocation through a solid-state nanopore.RSC advances · 2021Article
- Single molecule observation of hard-soft-acid-base (HSAB) interaction in engineeredChemical science · 2019Article
- A DNAzyme-amplified DNA circuit for highly accurate microRNA detection and intracellular imaging.Chemical science · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances have proven that using solid-state nanopores is a promising single molecular technique to enrich the DNA assembly signaling library. Other than using them for distinguishing structures, here we innovatively adapt solid-state nanopores for use in analyzing assembly mixtures, which is usually a tougher task for either traditional characterization techniques or nanopores themselves. A trigger induced DNA step polymerization (SP-CHA), producing three-way-DNA concatemers, is designed as a model. Through counting and integrating the translocation-induced current block when each concatemer passes through a glass conical glass nanopore, we propose an electrophoresis-gel like, but homogeneous, quantitative method that can comprehensively profile the "base-pair distribution" of SP-CHA concatemer mixtures. Due to the higher sensitivity, a number of super long concatemers that were previously difficult to detect
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Registered trials
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