Evidence map›Paper›PMID 30881619›Full record

ArticleMedChemComm2019

Quinolone-isoniazid hybrids: synthesis and preliminary

Richard M Beteck, Ronnett Seldon, Audrey Jordaan, Digby F Warner, Heinrich C Hoppe, Dustin Laming, Lesetja J Legoabe, Setshaba D Khanye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Updated Information on Antimicrobial Activity of Hydrazide-Hydrazones.International journal of molecular sciences · 2021
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Richard M BeteckFaculty of Science , Department of Chemistry , Rhodes University , Grahamstown 6140 , South Africa . Email: s.khanye@ru.ac.za.ORCID 0000-0002-6282-043X
Ronnett SeldonDrug Discovery and Development Centre (H3-D) , Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
Audrey JordaanSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit , Department of Pathology , University of Cape Town , Observatory , 7925 , South Africa.
Digby F WarnerSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit , Department of Pathology , University of Cape Town , Observatory , 7925 , South Africa.ORCID 0000-0002-4146-0930
Heinrich C HoppeFaculty of Science , Department of Biochemistry and Microbiology , Rhodes University , Grahamstown 6140 , South Africa.
Dustin LamingCentre for Chemico- and Biomedicinal Research , Rhodes University , Grahamstown 6140 , South Africa.
Lesetja J LegoabeCentre of Excellence for Pharmaceutical Science , North-West University , Potchefstroom 2520 , South Africa.ORCID 0000-0003-2440-4993
Setshaba D KhanyeFaculty of Science , Department of Chemistry , Rhodes University , Grahamstown 6140 , South Africa . Email: s.khanye@ru.ac.za.ORCID 0000-0003-0725-5738

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we propose novel quinolones incorporating an INH moiety as potential drug templates against TB. The quinolone-based compounds bearing an INH moiety attached

Identifiers

PMID30881619
PMCPMC6390685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.