Evidence map›Paper›PMID 30881610›Full record

ArticleMedChemComm2019

Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites.

Luísa Aguiar, Marta Machado, Margarida Sanches-Vaz, Miguel Prudêncio, Nuno Vale, Paula Gomes

Abstract read
In one paragraph

Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Primaquine derivatives: Modifications of the terminal amino group.European journal of medicinal chemistry · 2019
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luísa AguiarLAQV-REQUIMTE , Departamento de Química e Bioquímica , Faculdade de Ciências , Universidade do Porto , Rua do Campo Alegre 687 , P-4169-007 Porto , Portugal . Email: pgomes@fc.up.pt.
Marta MachadoInstituto de Medicina Molecular João Lobo Antunes , Faculdade de Medicina , Universidade de Lisboa , Avenida Professor Egas Moniz , P-1648-028 Lisboa , Portugal.
Margarida Sanches-VazInstituto de Medicina Molecular João Lobo Antunes , Faculdade de Medicina , Universidade de Lisboa , Avenida Professor Egas Moniz , P-1648-028 Lisboa , Portugal.
Miguel PrudêncioInstituto de Medicina Molecular João Lobo Antunes , Faculdade de Medicina , Universidade de Lisboa , Avenida Professor Egas Moniz , P-1648-028 Lisboa , Portugal.ORCID 0000-0003-1746-6029
Nuno ValeLaboratório de Farmacologia , Departamento de Ciências do Medicamento , Faculdade de Farmácia , Universidade do Porto , Rua de Jorge Viterbo Ferreira 228 , P-4050-313 Porto , Portugal.
Paula GomesLAQV-REQUIMTE , Departamento de Química e Bioquímica , Faculdade de Ciências , Universidade do Porto , Rua do Campo Alegre 687 , P-4169-007 Porto , Portugal . Email: pgomes@fc.up.pt.ORCID 0000-0002-6018-4724

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel primaquine-cell penetrating peptide conjugates were synthesised and tested

Identifiers

PMID30881610
PMCPMC6390471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.