ReviewThe western journal of emergency medicine2019
Challenging the One-hour Sepsis Bundle.
Review in The western journal of emergency medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Effect of the 1-h bundle on mortality in patients with suspected sepsis in the emergency department: a stepped wedge cluster randomized clinical trial.Intensive care medicine · 2024Trial
- The relationship between sepsis bundle delay intervals and in-hospital mortality of sepsis patients in ICU.Frontiers in medicine · 2026Article
- Timing of Core Sepsis Bundle Elements Initiation in Critically Ill Patients: A Multicenter Target Trial Emulation Study.Clinical epidemiology · 2026Article
- Article
- Head-to-head comparison of pre-hospital qSOFA and lactate-qSOFA for predicting sepsis in patients with and without suspected infection. A multicenter prospective cohort study.Archives of medical science : AMS · 2024Article
- Risk of Misleading Conclusions in Observational Studies of Time-to-Antibiotics and Mortality in Suspected Sepsis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- The diagnostic accuracy of an initial point-of-care lactate at the emergency department as a predictor of in-hospital mortality among adult patients with sepsis and septic shock.Frontiers in medicine · 2023Article
- Relationship Between the Use of Preprinted Physician Orders for Hospital-Acquired Fever and Time to Blood Culture Collection: A Single-Center Retrospective Cross-Sectional Study.International journal of general medicine · 2022Article
- Analysis of Blood Culture Data Influences Future Epidemiology of Bloodstream Infections: A 5-year Retrospective Study at a Tertiary Care Hospital in India.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Time to administration of antibiotics and mortality in sepsis.Journal of the American College of Emergency Physicians open · 2021Article
- Effectiveness of sepsis bundle application and outcomes predictors to cirrhotic patients with septic shock.BMC infectious diseases · 2021Article
- Application of a Mapping Function to Estimate Utilities for Ragweed Allergy Immunotherapy Trials.PharmacoEconomics - open · 2020Article
- Timeliness of antibiotics for patients with sepsis and septic shock.Journal of thoracic disease · 2020Review
- A New Way Forward in the Emergency Department.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2019Article
- Burnout, Drop Out, Suicide: Physician Loss in Emergency Medicine, Part I.The western journal of emergency medicine · 2019Review
- Sepsis Care Pathway 2019.Qatar medical journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In April 2018, the Surviving Sepsis Campaign (SSC) released an updated sepsis bundle, which combines directives previously listed in the three-hour and six-hour bundles. The authors discussed the reasoning and evidence supporting these changes. However, there are data that suggest these recommendations may be contrary to the best available evidence. Our purpose here is to highlight the areas where evidence is only as strong as the methodological constructs of the research used. This article is a narrative review of the available, limited evidence on which the one-hour bundle was based.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.