Evidence map›Paper›PMID 30881283›Full record

ArticleFrontiers in neuroscience2019

Tim Indersmitten, Michael J Schachter, Stephanie Young, Natalie Welty, Stephani Otte, Jonathan J Nassi, Timothy Lovenberg, Pascal Bonaventure, Ryan M Wyatt

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tim IndersmittenJanssen Research & Development, LLC., San Diego, CA, United States.
Michael J SchachterInscopix, Palo Alto, CA, United States.
Stephanie YoungJanssen Research & Development, LLC., San Diego, CA, United States.
Natalie WeltyJanssen Research & Development, LLC., San Diego, CA, United States.
Stephani OtteJanssen Research & Development, LLC., San Diego, CA, United States.
Jonathan J NassiJanssen Research & Development, LLC., San Diego, CA, United States.
Timothy LovenbergJanssen Research & Development, LLC., San Diego, CA, United States.
Pascal BonaventureJanssen Research & Development, LLC., San Diego, CA, United States.
Ryan M WyattJanssen Research & Development, LLC., San Diego, CA, United States.
Janssen (United States) · USInscopix (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hippocampus, a structure essential for spatial navigation and memory undergoes anatomical and functional changes during chronic stress. Here, we investigate the effects of chronic stress on the ability of place cells to encode the neural representation of a linear track. To model physiological conditions of chronic stress on hippocampal function, transgenic mice expressing the genetically encoded calcium indicator GCaMP6f in CA1 pyramidal neurons were chronically administered with 40 μg/ml of cortisol for 8 weeks. Cortisol-treated mice exhibited symptoms typically observed during chronic stress, including diminished reward seeking behavior and reduced adrenal gland and spleen weights.

Indexed as

calcium imagingcitalopramcortisolGCaMP6fminiature microscopesplace cellstransgenic mice

Identifiers

PMID30881283
PMCPMC6405689
OpenAlexW2918589772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.