Evidence map›Paper›PMID 30881242›Full record

ArticleIntegrative medicine (Encinitas, Calif.)2017

Cardiac Lymphatics: An Example of Systems Biology in Medicine.

Jeffrey Bland

Abstract read
In one paragraph

Article in Integrative medicine (Encinitas, Calif.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jeffrey Bland

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When evaluated from the 2017 perspective, the 1981 Lemole cardiac lymphatic drainage model for the origin of atherosclerosis appears very prescient. The concept proposed by Dr Lemole is rooted in a systems biology understanding of the origin of disease (itself a very novel concept in 1981). The Lemole hypothesis for the origin of atherosclerosis pioneered the application of systems thinking in cardiology and brought the importance of lifestyle factors and physical medicine approaches for the prevention and treatment of cardiac disease to the threshold of a mechanistic understanding. It is this type of systems biology approach to clinical problem solving that forms the heuristic of the functional medicine model.

Identifiers

PMID30881242
PMCPMC6419778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.