Evidence map›Paper›PMID 30881124›Full record

ArticleCancer management and research2019

Upregulated circ RNA hsa_circ_0000337 promotes cell proliferation, migration, and invasion of esophageal squamous cell carcinoma.

Huan Song, Dian Xu, Peiyi Shi, Biyu He, Zhongqi Li, Ye Ji, Charles Kwaku Agbeko, Jianming Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer management and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Huan SongDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, People's Republic of China, jmwang@njmu.edu.cn.
Dian XuDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, People's Republic of China, jmwang@njmu.edu.cn.
Peiyi ShiDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, People's Republic of China, jmwang@njmu.edu.cn.
Biyu HeDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, People's Republic of China, jmwang@njmu.edu.cn.
Zhongqi LiDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, People's Republic of China, jmwang@njmu.edu.cn.
Ye JiDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, People's Republic of China, jmwang@njmu.edu.cn.
Charles Kwaku AgbekoDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, People's Republic of China, jmwang@njmu.edu.cn.
Jianming WangDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, People's Republic of China, jmwang@njmu.edu.cn.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs a new class of endogenous ncRNAs, circRNAs have been recently verified to be involved in the carcinogenesis and progression of human cancers. In the current study, we attempted to explore the potential function of a candidate circRNA (hsa_circ_0000337) in esophageal squamous cell carcinoma (ESCC). PATIENTS AND

methodsThe altered expression of hsa_circ_0000337 was validated in clinical samples from 48 patients with ESCC. The human esophageal carcinoma cell lines KYSE-150 and TE-1, and the normal human esophageal epithelial cell line (HET-1A) were applied for functional analysis of hsa_circ_0000337. Cell proliferation was measured using the Cell Counting Kit-8 assay and the colony formation assay. Cell invasion and migration were detected by Transwell and wound healing assays, respectively. We further performed bioinformatic analysis and luciferase reporter assays to explore the role of hsa_circ_0000337 as a miRNA sponge.

resultshsa_circ_0000337 was significantly upregulated in ESCC tissues compared to adjacent normal-appearing tissues (

conclusionhsa_circ_0000337 was found to be an upregulated circRNA that is related to ESCC and promotes the progression of disease by regulating cell proliferation, migration, and invasion. These findings suggest that this circRNA could be a promising diagnostic biomarker and potential therapeutic target.

Indexed as

biomarkeresophageal squamous cell carcinomaRNAsmall untranslateduntranslated RNA

Identifiers

PMID30881124
PMCPMC6407512
OpenAlexW2920730547

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.