ArticleLocal and regional anesthesia2019
Spinal anesthesia-induced hypotension is caused by a decrease in stroke volume in elderly patients.
Article in Local and regional anesthesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06431568 (Effect of Prophylactic IV Ondansetron Prior Spinal Anaesthesia in Caesarean Section on Bradycardia and Hypotension), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Prophylactic IV Ondansetron Prior Spinal Anaesthesia in Caesarean Section on Bradycardia and Hypotension (Observational Study)
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Hypotension after unilateral versus bilateral spinal anaesthesia: A Systematic review with meta-analysis.European journal of anaesthesiology · 2025Pooled it
- The use of preoperative inferior vena cava ultrasound to predict anaesthesia-induced hypotension: a systematic review.Anaesthesiology intensive therapy · 2023Pooled it
- Hemodynamic effects of norepinephrine versus phenylephrine infusion for prophylaxis against spinal anesthesia-induced hypotension in the elderly population undergoing hip fracture surgery: a randomized controlled trial.Korean journal of anesthesiology · 2021Trial
- Spinal anesthesia versus combined sciatic nerve/lumbar plexus nerve block in elderly patients undergoing total hip arthroplasty: a retrospective study.Annals of Saudi medicineTrial
- Association Between Immediate Postoperative Pulse Pressure and Three-Year All-Cause Mortality After Hip Fracture Surgery in Older Adults: A Post Hoc Analysis of a Prospective Cohort.Journal of clinical medicine · 2026Article
- Continuous Spinal Anesthesia in Frail Patients Undergoing Orthopedic Hip and Knee Revision Surgery: Advantages, Indications, and Risk Management-A Single-Center Retrospective Experience.Journal of clinical medicine · 2026Article
- Comparison of the efficacy and safety of thoracic epidural and paravertebral block in postoperative analgesia after thoracic surgery: a meta-analysis of randomized trials.Frontiers in medicine · 2026Review
- A Retrospective Observational Study of Ephedrine Use in Hip Arthroplasty: Routine Practice at a Secondary Care Hospital in Romania.Clinics and practice · 2025Article
- Outcomes of Transurethral Resection of the Prostate (TURP) in High-Risk Cardiac Patients Under Spinal Anesthesia.Cureus · 2025Article
- Article
- Preoperative echocardiography as a predictor of spinal anesthesia-induced hypotension in older patients with mild left ventricular diastolic dysfunction: a retrospective observational study.Anesthesia and pain medicine · 2024Article
- Intrathecal Injection of Hyperbaric Bupivacaine Versus a Mixture of Hyperbaric and Isobaric Bupivacaine in Lower Abdominal Surgery: A Randomized Controlled Trial.Anesthesiology and pain medicine · 2023Article
- Review
- Effects of neuraxial or general anaesthesia on postoperative adverse events in oldest-old patients (aged 90 years and older) with intertrochanteric fractures: a retrospective study.BMC musculoskeletal disorders · 2023Article
- A Randomized, Double-Blind, Graded Dose-Response Study of Norepinephrine Administration for Prevention of Post-Spinal Hypotension during Elective Cesarean Delivery.Journal of clinical medicine · 2023Article
- Comparison of the effects of spinal anesthesia, paracervical block and general anesthesia on pain, nausea and vomiting, and analgesic requirements in diagnostic hysteroscopy: A non-randomized clinical trial.Frontiers in medicine · 2023Article
- Article
- Article
- Dural sac cross-sectional area measured using ultrasound to modify the dosage of local anaesthetic in spinal anaesthesia for transurethral resection of prostate surgery: A prospective, double blind, randomised controlled study.Indian journal of anaesthesia · 2022Article
- Comparison between 10 and 12 mg doses of intrathecal hyperbaric (0.5%) bupivacaine on sensory block level after first spinal failure in cesarean section: A double-blind, randomized clinical trial.Frontiers in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypotension is common during spinal anesthesia (SA) and is caused by a decrease in systemic vascular resistance (SVR) and/or cardiac output (CO). The effect of the dose of bupivacaine administered intrathecally on the changes in CO in elderly patients is largely unknown. This study investigated the hemodynamic effect of SA in elderly patients by studying the effect of two different dosages of intrathecal bupivacaine.
methodsThis prospective cohort study included 64 patients aged >65 years scheduled for procedures under SA; the patients received either 15 mg bupivacaine (the medium dose [MD] group) or 10 mg bupivacaine and 5 μg sufentanil (the low dose [LD] group). Blood pressure and CO were monitored throughout the procedure using Nexfin™, a noninvasive continuous monitoring device using a finger cuff.
resultsThirty-three patients received MD and 31 received LD and there was no mean difference in baseline hemodynamics between the groups. On an average, the CO decreased 11.6% in the MD group and 10.0 % in the LD group. There was no significant change in SVR. Incidence of a clinically relevant decrease in stroke volume (SV) (>15% from baseline) was 67% in the MD and 45% in the LD groups (
conclusionCO and blood pressure decreased significantly after the onset of SA in elderly patients. This is mainly caused by a decrease in SV and not by a decrease in SVR. There was no difference in CO and blood pressure change between dosages of 10 or 15 mg bupivacaine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.