ArticleClinicoEconomics and outcomes research : CEOR2019
Health-related quality of life outcomes, economic burden, and associated costs among diagnosed and undiagnosed depression patients in Japan.
Article in ClinicoEconomics and outcomes research : CEOR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Global economic burden of depression in 154 countries from 2025 to 2050.Nature medicine · 2026Article
- The social and healthcare burden of major depressive disorder in adults: an Italian observational cohort study.BMC public health · 2026Observational
- Identifying Physiological and Cognitive Indicators of Subthreshold Depression and Major Depressive Disorder Progression Risk.Neuropsychiatric disease and treatment · 2026Article
- Work productivity by diseases diagnosed among workers: a study using large-scale claims data and survey data of workers in Japan.Journal of occupational health · 2025Article
- Profile of individuals served and presumed coverage of Psychosocial Care Centers (CAPS) in Brazil: A study of the period 2013-2019.PloS one · 2024Article
- Patterns, predictors, and patient-reported reasons for antidepressant discontinuation in the WHO World Mental Health Surveys.Psychological medicine · 2024Review
- Health outcomes and healthcare utilization associated with four undiagnosed chronic conditions: evidence from nationally representative survey data in Sri Lanka.BMC global and public health · 2024Article
- Humanistic and economic burden associated with depression in the United States: a cross-sectional survey analysis.BMC psychiatry · 2022Article
- Determinants of effective treatment coverage for major depressive disorder in the WHO World Mental Health Surveys.International journal of mental health systems · 2022Article
- Inequalities in the prevalence of major depressive disorder in Brazilian slum populations: a cross-sectional analysis.Epidemiology and psychiatric sciences · 2021Article
- Healthcare use and costs in adult cancer patients with anxiety and depression.Depression and anxiety · 2020Article
- Effect of a brief cognitive behavioral program on depressive symptoms among newly licensed registered nurses: An observational study.PloS one · 2020Observational
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDepression is associated with substantial health and economic burden. This study examined the impact of diagnosed and undiagnosed depression on health-related outcomes and costs among Japanese adults.
methodsA retrospective, observational study was conducted using 2012-2014 Japan National Health and Wellness Survey (N=83,504) data. Differences between respondents diagnosed with depression (n=2,843) and undiagnosed with depression (weighted n=2,717) and controls without depression (weighted n=2,801) in health-related quality of life, impairment to work productivity and daily activities (Work Productivity and Activity Impairment Questionnaire), health care resource utilization, and annual costs were evaluated. Propensity score weighting and weighted generalized linear models were used to compare groups on the outcome variables, after adjusting for covariates.
resultsOverall, respondents with undiagnosed depression had significantly better outcomes than those diagnosed with depression, but significantly worse outcomes than controls (for all,
conclusionDiagnosed depression was associated with lower health-related quality of life and greater impairment in work productivity and daily activities, higher health care resource utilization, and higher costs, compared with undiagnosed respondents and controls. These study findings suggest a need for greater awareness of depression symptoms among Japanese adults, which is needed to facilitate proper diagnosis and treatment.
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