ArticleInfection and drug resistance2019
Profiles of hematological parameters in
Article in Infection and drug resistance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Prevalence of thrombocytopenia among patients with malaria in Ethiopia: a systematic review and metanalysis.Malaria journal · 2025Pooled it
- Plasmodium vivax epidemiology in Ethiopia 2000-2020: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2021Pooled it
- Reduction in total leukocytes in malaria patients compared to febrile controls: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Therapeutic efficacy, safety and gametocyte clearance after antimalarial treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax malaria in Northeast Ethiopia.Scientific reports · 2026Observational
- Clinical characteristics of thrombocytopenia in tropical diseases and management in resource-limited settings.Research and practice in thrombosis and haemostasis · 2026Review
- Naturally acquired malaria is associated with shorter leukocyte relative telomere length and increased hTERT expression in an endemic nigerian population.Frontiers in cellular and infection microbiology · 2026Article
- Seasonal Climate Drivers and Immunohematological Profiles of Malaria in Rohingya Refugee Camps, Bangladesh: A 4-Year Repeated Cross-Sectional Study.Journal of parasitology research · 2026Article
- Distinct gastrointestinal microbial signatures predict parasite levels in controlled Plasmodium infections in both rhesus macaques and humans.Nature communications · 2025Article
- Unsuspected Malaria Infection in a Case with PancytopeniaBalkan medical journal · 2025Article
- Coinfection of COVID-19 and malaria: clinical profiles, interactions, and strategies for effective control.Malaria journal · 2025Review
- Plasma Soluble Progenitor Cell Receptors as Biomarkers for Severe Anemia Among Malaria-Infected Pediatrics: A Prospective Study in Ghana.Health science reports · 2025Article
- Haematological abnormalities as diagnostic indicators of malaria in returning travellers: a retrospective study at Mohamed V Military Instruction Hospital.Access microbiology · 2025Article
- Stress-mediating inflammatory cytokine profiling reveals unique patterns in malaria and typhoid fever patients.PloS one · 2025Observational
- Hematological Profiles of Adults Coinfected With HIV and Malaria Receiving Highly Active Antiretroviral Therapy at Bonga Gebretsadik Shawo General Hospital, Southwest Ethiopia: A Comparative Cross-Sectional Study.Advances in hematology · 2025Article
- UHPLC/MS Profile and Antimalarial Potency ofAdvances in pharmacological and pharmaceutical sciences · 2025Article
- Basic coagulation parameters and platelet count among malaria patients attending at Addis Zemen Primary Hospital, Northwest Ethiopia.BMC infectious diseases · 2024Article
- Pro- and anti-inflammatory cytokines mediate the progression of severe anemia in malaria-infected children: A prospective study.Immunity, inflammation and disease · 2024Article
- Haematological Profile in Patients With Acute Falciparum Malaria: A Hospital-Based Study.Cureus · 2024Article
- Assessment of the selected hematological profiles among malaria andJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Elevation of free triiodothyronine (fT3) levels by Plasmodium falciparum independent of thyroid stimulating hormone (TSH) in children with uncomplicated malaria.Journal of clinical laboratory analysis · 2024Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalaria is a major health problem in the tropics, with 300-500 million cases and 1.1-2.7 million deaths occurring annually. The hematological alterations associated with malaria infection may vary depending on: level of malaria endemicity, background hemoglobinopathy, malaria immunity, host genetic factors, and parasite strain variations.
objectiveThe aim of the study was to determine the profiles of hematologic parameters in METHODOLOGY: A total of 340 study participants were included in the study, out of which 170 were malaria cases, and the remaining 170 were malaria negatives. An institution-based cross-sectional study was conducted. Malaria diagnosis was based on thick and thin blood films microscopy. Hematological parameters were determined by using an automated, CELL-DYN 1800 hematology analyzer. Malaria parasite density was determined by counting the asexual parasites against 200 WBCs, and then calculated by using the standard formula. The diagnostic accuracy of hematological parameters was measured by computing sensitivity, specificity, and likelihood ratios.
resultsThe mean values of Hgb, Hct, platelet, WBC, RBC, and lymphocyte were significantly lower in malaria patients than malaria negatives. The prevalence of thrombocytopenia and anemia in malaria patients was 84% and 67%, respectively. There was an inverse correlation between CONCLUSION AND RECOMMENDATION: Thrombocytopenia and anemia were the two common hematological abnormalities observed in malaria cases. The platelet count during malaria infection was inversely correlated with the asexual stage parasite density. Patients with acute febrile illness having thrombocytopenia should alert the treating physician about the possibility of malaria infection. Malaria patients should be checked for the presence of hematological abnormalities such as anemia and have to be managed for those abnormalities.
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