Evidence map›Paper›PMID 30881052›Full record

ArticleInfection and drug resistance2019

Antimicrobial resistance, virulence genes profiling and molecular relatedness of methicillin-resistant

Yingjian Liang, Changli Tu, Cuiyan Tan, Mohamed Abd El-Gawad El-Sayed Ahmed, Min Dai, Yong Xia, Yan Liu, Lan-Lan Zhong, Cong Shen, Guanping Chen and 3 more

Abstract read
In one paragraph

Article in Infection and drug resistance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
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  3. Article
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  6. Article
  7. Spectrum of Virulence Factors in Clinical Isolates ofJournal of laboratory physicians · 2023
    Article
  8. Article
  9. Antimicrobial resistance profile of methicillin-resistantFrontiers in cellular and infection microbiology · 2023
    Article
  10. Molecular typing and characterization ofFrontiers in microbiology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Genomic Investigation of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Frontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yingjian LiangDepartment of Respiratory Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China, zhxbin@sysu.edu.cn; jliu01@jlu.edu.cn.
Changli TuDepartment of Respiratory Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China, zhxbin@sysu.edu.cn; jliu01@jlu.edu.cn.
Cuiyan TanDepartment of Respiratory Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China, zhxbin@sysu.edu.cn; jliu01@jlu.edu.cn.
Mohamed Abd El-Gawad El-Sayed AhmedDepartment of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Min DaiSchool of Laboratory Medicine, Chengdu Medical College, Chengdu, China.
Yong XiaDepartment of Clinical Laboratory Medicine, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yan LiuClinical laboratory, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.
Lan-Lan ZhongDepartment of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Cong ShenDepartment of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Guanping ChenDepartment of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Guo-Bao TianDepartment of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Jing LiuDepartment of Respiratory Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China, zhxbin@sysu.edu.cn; jliu01@jlu.edu.cn.
Xiaobin ZhengDepartment of Respiratory Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China, zhxbin@sysu.edu.cn; jliu01@jlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe main objective of this study was to decipher the prevalence, antimicrobial resistance, major virulence genes and the molecular characteristics of methicillin-resistant MATERIALS AND

methodsThe present study was performed on 187 non-duplicate

resultsOut of 187 isolates, 103 (55%) were identified as MRSA. The highest prevalence rate was found among the skin and soft tissue infection (SSTI) samples (58/103), followed by sputum samples (25/103), blood stream infection samples (15/103) and others (5/103). Antimicrobial susceptibility results revealed high resistance rates for erythromycin (64.1%), clindamycin (48.5%), gentamicin (36.9%) and ciprofloxacin (33.98%). All isolates were susceptible to vancomycin. Resistance genes and mutation detected were as follows:

conclusionOur study elucidated the prevalence, antibiotic resistance, pathogenicity and molecular characteristics of MRSA isolated from various clinical sources in Guangdong, China. We found that the infectious rate of MRSA was higher among SSTI than other sources. The most predominant genotype was ST239-SCCmecA III-t37 clone, indicating that ST239-t30 clone which was previously predominant had been replaced by a new clone.

Indexed as

antibiotic resistancemolecular typingMRSAresistance genesvirulence factorswhole genome sequencing

Identifiers

PMID30881052
PMCPMC6394240

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.