Evidence map›Paper›PMID 30880982›Full record

ArticleInternational journal of nanomedicine2019

Development of anisamide-targeted PEGylated gold nanorods to deliver epirubicin for chemo-photothermal therapy in tumor-bearing mice.

Limei Wang, Jin Pei, Zhongcheng Cong, Yifang Zou, Tianmeng Sun, Fionán Davitt, Adrià Garcia-Gil, Justin D Holmes, Caitriona M O'Driscoll, Kamil Rahme and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 31 citations in OpenAlex.

  1. ZIF-8 nanoplatform coordinating ZnInternational journal of pharmaceutics: X · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Thermal analysis of laser irradiation-gold nanorod combinations at 808 nm, 940 nm, 975 nm and 1064 nm wavelengths in breast cancer model.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2021
    Article
  7. Review
  8. Gold Nanoparticles: A New Golden Era in Oncology?Pharmaceuticals (Basel, Switzerland) · 2020
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Limei WangSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China, peijin@jlu.edu.cn; jguo@jlu.edu.cn.
Jin PeiSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China, peijin@jlu.edu.cn; jguo@jlu.edu.cn.
Zhongcheng CongSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China, peijin@jlu.edu.cn; jguo@jlu.edu.cn.
Yifang ZouSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China, peijin@jlu.edu.cn; jguo@jlu.edu.cn.
Tianmeng SunThe First Hospital of Jilin University, Changchun 130021, China.
Fionán DavittSchool of Chemistry and the Tyndall National Institute, University College Cork, Cork, Ireland.
Adrià Garcia-GilSchool of Chemistry and the Tyndall National Institute, University College Cork, Cork, Ireland.
Justin D HolmesSchool of Chemistry and the Tyndall National Institute, University College Cork, Cork, Ireland.
Caitriona M O'DriscollPharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland.
Kamil RahmeSchool of Chemistry and the Tyndall National Institute, University College Cork, Cork, Ireland.
Jianfeng GuoSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China, peijin@jlu.edu.cn; jguo@jlu.edu.cn.
Jilin University · CNNational University of Ireland · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGold nanorods (AuNRs), due to the optical and electronic properties namely the surface plasma resonance, have been developed to achieve the light-mediated photothermal therapy (PTT) for cancer. However, PTT alone may suffer from inefficient tumor killing. Recently, the combination of PTT and chemotherapy has been utilized to achieve synergistic anticancer effects.

methodsIn this study, AuNRs capped with hexadecyltrimethylammonium bromide (CTAB), poly(acrylic acid) (PAA), and PEGylated anisamide (a ligand known to target the sigma receptor) have been developed to produce a range of negatively charged anisamide-targeted PEGylated AuNRs (namely Au-CTAB-PAA-PEG-AA) for the combination of PTT and chemotherapy (termed as chemo-photothermal therapy [CPTT]). Epirubicin (EPI, an anthracycline drug) was efficiently loaded onto the surface of Au

resultsThe resultant complex demonstrated pH-dependent drug release, facilitated nucleus trafficking of EPI, and induced antiproliferative effects in human prostate cancer PC-3 cells. When Au

conclusionThese results demonstrate a promising strategy for clinical application of CPTT in cancer.

Indexed as

Drug Delivery SystemsHyperthermia, InducedPhototherapyAnimalsAntineoplastic AgentsBenzamidesCaspasesCell Line, TumorCell SurvivalDrug LiberationEndocytosisEpirubicinGoldHumansIntracellular SpaceMaleAntineoplastic AgentsBenzamidesCaspasesEpirubicinGoldPolyethylene Glycolschemotherapygold nanoparticlesnon-viral drug deliveryphotothermal therapysynergistic effect

Identifiers

PMID30880982
PMCPMC6413758
OpenAlexW2921980694

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.