ArticleInternational journal of chronic obstructive pulmonary disease
Eosinophil levels predict lung function deterioration in apparently healthy individuals.
Article in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Clinical Remission in Severe Asthma: A Comparative Analysis of Patients with and Without Biologics from the Swiss Severe Asthma Registry.Biomedicines · 2025Article
- Uncontrolled asthma from childhood to young adulthood associates with airflow obstruction.ERJ open research · 2021Article
- The influence of individual characteristics and non-respiratory diseases on blood eosinophil count.Clinical and translational allergy · 2021Article
- Blood eosinophil level and lung function trajectories: cross-sectional and longitudinal studies in European cohorts.ERJ open research · 2020Article
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9 authors.
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Abstract
backgroundWhile chronic respiratory diseases are among the leading causes of mortality and morbidity worldwide, little is known about the effect of blood eosinophil levels on lung function trajectories among healthy individuals.
methodsWe analyzed data of apparently healthy individuals (n=18,089) recruited for the Tel Aviv Medical Center Inflammation Survey. Blood eosinophil levels were compared between participants with normal and those with abnormal lung function. Multivariate regression was used to assess the OR of forced expiratory volume in 1 second (FEV
resultsParticipants with an abnormal, as opposed to a normal, pulmonary function test (PFT) (n=1,832, 10.1%) had significantly higher eosinophil levels, expressed as a percentage or count (2.99%±2.00% compared to 2.67%±1.88% and 0.2210e3/µL±0.163/µL compared to 0.1810e3/µL±0.183/µL, respectively;
conclusionOur study suggests that higher blood eosinophil levels can predict PFT deterioration even in apparently healthy subjects, implying that these individuals could benefit from frequent lung function evaluation.
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