Evidence map›Paper›PMID 30880946›Full record

ArticleInternational journal of chronic obstructive pulmonary disease

Clinical phenotypes of COPD and health-related quality of life: a cross-sectional study.

Chee-Shee Chai, Chong-Kin Liam, Yong-Kek Pang, Diana Leh-Ching Ng, Seng-Beng Tan, Tat-Seng Wong, Jo-Ee Sia

Abstract readComparative Study
In one paragraph

Article in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  13. RETRO-POPE: A Retrospective, Multicenter, Real-World Study of All-Cause Mortality in COPD.International journal of chronic obstructive pulmonary disease · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chee-Shee ChaiDepartment of Medicine, Faculty of Medicine and Health Science, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia.
Chong-Kin LiamDepartment of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, liamck@ummc.edu.my.
Yong-Kek PangDepartment of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, liamck@ummc.edu.my.
Diana Leh-Ching NgDepartment of Medicine, Faculty of Medicine and Health Science, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia.
Seng-Beng TanDepartment of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, liamck@ummc.edu.my.
Tat-Seng WongDepartment of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, liamck@ummc.edu.my.
Jo-Ee SiaDepartment of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, liamck@ummc.edu.my.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Spanish COPD guideline (GesEPOC) classifies COPD into four clinical phenotypes based on the exacerbation frequency and dominant clinical manifestations. In this study, we compared the disease-specific health-related quality of life (HRQoL) of patients with different clinical phenotypes.

methodsThis was a cross-sectional study of patients with COPD attending the respiratory medicine clinic of University of Malaya Medical Centre from 1 June 2017 to 31 May 2018. Disease-specific HRQoL was assessed by using the COPD Assessment Test (CAT) and St George's Respiratory Questionnaire for COPD (SGRQ-c).

resultsOf 189 patients, 28.6% were of non-exacerbator phenotype (NON-AE), 18.5% were of exacerbator with emphysema phenotype (AE NON-CB), 39.7% were of exacerbator with chronic bronchitis phenotype (AE CB), and 13.2% had asthma-COPD overlap syndrome phenotype (ACOS). The total CAT and SGRQ-c scores were significantly different between the clinical phenotypes (

conclusionPatients who were AE CB had significantly poorer HRQoL than other clinical phenotypes and recorded the worst score in each of the CAT items and SGRQ-c components. Therefore, AE CB patients may warrant a different treatment approach that focuses on the exacerbation and chronic bronchitis components.

Indexed as

Quality of LifeAgedAged, 80 and overAsthmaBronchitis, ChronicCross-Sectional StudiesDisease ProgressionFemaleForced Expiratory VolumeHealth StatusHumansLungMalaysiaMaleMiddle AgedPhenotypeasthmachronic bronchitischronic obstructive pulmonary diseaseclinical phenotypesemphysemaexacerbationhealth-related quality of life

Identifiers

PMID30880946
PMCPMC6402617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.