Evidence map›Paper›PMID 30880927›Full record

ArticleClinical interventions in aging2019

Investigating the utility of teletherapy in individuals with primary progressive aphasia.

Heather R Dial, Holly A Hinshelwood, Stephanie M Grasso, H Isabel Hubbard, Maria-Luisa Gorno-Tempini, Maya L Henry

4 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Clinical interventions in aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04881617 naactive not recruitingnot on this map

Establishing Evidence-based Treatment for Speech and Language in Primary Progressive Aphasia

TypeinterventionalSponsorUniversity of Texas at AustinRan2017 to 2025Enrolled60ConditionsPrimary Progressive Aphasia, Semantic Dementia, Semantic Memory Disorder, Logopenic Progressive AphasiaArmsLexical Retrieval Training (LRT), Video-Implemented Script Training for Aphasia (VISTA)
NCT05901233 naenrolling by invitationnot on this mapstarted 2023, after this paper: background citation

Telerehabilitation With Remotely-Supervised tDCS in Progressive Aphasia

TypeinterventionalSponsorUniversity of Texas at AustinRan2023 to 2026Enrolled10ConditionsPrimary Progressive AphasiaArmsRemotely supervised Transcranial Direct Current Stimulation (RS-tDCS), Remotely supervised sham tDCS (RS-sham-tDCS), Lexical Retrieval Training (LRT), Video Implemented Script Training in Aphasia (VISTA)
NCT07219680 narecruitingnot on this mapstarted 2026, after this paper: background citation

Intervention to Promote Communication Quality of Life for Persons With Language-Led Dementia and Their Partners: A Randomized Pilot Trial

TypeinterventionalSponsorMaya HenryRan2026 to 2027Enrolled30ConditionsPrimary Progressive Aphasia(PPA), Semantic Dementia, Logopenic Progressive Aphasia (LPA), Nonfluent Aphasia, ProgressiveArmsMulticomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia
NCT07260253 narecruitingnot on this mapstarted 2026, after this paper: background citation

Investigating the Benefits of Remotely-Supervised Neuromodulation In Primary Progressive Aphasia

TypeinterventionalSponsorMaya HenryRan2026 to 2029Enrolled80ConditionsPrimary Progressive Aphasia(PPA), Progressive Aphasia, Progressive Aphasia in Alzheimer's Disease, Logopenic Progressive Aphasia (LPA)ArmsLexical Retrieval Cascade Treatment, Remotely Supervised Transcranial Direct Current Stimulation- Active, Remotely Supervised Transcranial Direct Current Stimulation - Sham
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
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  10. Review
  11. Investigating changes in connected speech in nonfluent/agrammatic primary progressive aphasia following script training.Cortex; a journal devoted to the study of the nervous system and behavior · 2025
    Article
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  16. Rehabilitation Services for Young-Onset Dementia: Examples from High- and Low-Middle-Income Countries.International journal of environmental research and public health · 2024
    Review
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  19. Article
  20. New Approaches to the Treatment of Frontotemporal Dementia.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Heather R DialCommunication Sciences and Disorders, University of Texas at Austin, Austin, TX, USA, heather.raye.dial@gmail.com.
Holly A HinshelwoodSpeech Pathology, Wake Forest Baptist Health, Winston-Salem, NC, USA.
Stephanie M GrassoCommunication Sciences and Disorders, University of Texas at Austin, Austin, TX, USA, heather.raye.dial@gmail.com.
H Isabel HubbardCommunication Sciences and Disorders, University of Alberta, Edmonton, AB, Canada.
Maria-Luisa Gorno-TempiniMemory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
Maya L HenryCommunication Sciences and Disorders, University of Texas at Austin, Austin, TX, USA, heather.raye.dial@gmail.com.
The University of Texas at Austin · USAtrium Health Wake Forest Baptist · USUniversity of Alberta · CAUniversity of California, San Francisco · US

Funding

PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, YADONG · 2004 to 2018
$27.1M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Connectomic imaging in familial and sporadic frontotemporal degenerationU01AG052943 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GORNO TEMPINI, MARIA LUISA, GROSSMAN, MURRAY · 2016 to 2019
$5.9M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaR01NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, John Francis Houde · 2017 to 2026
$3.6M
Establishing Evidence-based Treatment for Speech and Language in Primary Progressive AphasiaR01DC016291 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI HENRY, MAYA · 2017 to 2021
$3.3M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Rehabilitation of speech and language in primary progressive aphasiaR03DC013403 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI HENRY, MAYA · 2014 to 2016
$565k
Primary Progessive Aphasia: Cognition, Anatomy and ProgressionR56NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2008 to 2008
$315k
Establishing Evidence-based Treatment for Speech and Language in Primary Progressive AphasiaR56DC016291 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI HENRY, MAYA · 2023 to 2023
$97k
NIA NIH HHS P50 AG023501NIA NIH HHS U01 AG052943NIDCD NIH HHS K24 DC015544NIDCD NIH HHS R01 DC016291NIDCD NIH HHS R03 DC013403NIDCD NIH HHS R56 DC016291NINDS NIH HHS R01 NS050915NINDS NIH HHS R01 NS100440NINDS NIH HHS R56 NS050915
6 · The paper itself

Abstract

introductionPrimary progressive aphasia (PPA) is a neurodegenerative disorder characterized by progressive deterioration of speech and language. A growing body of research supports the utility of speech and language intervention in individuals with PPA, although access to these services remains limited. One potential means of increasing treatment accessibility is the delivery of treatment via telemedicine. Evidence supports the use of teletherapy in stroke-induced aphasia, but research examining the application of teletherapy in PPA is limited. In the current study, a non-randomized group comparison design was used to evaluate the feasibility and utility of treatment delivered via teletherapy relative to treatment administered in person for individuals with PPA.

methodsTwo treatment protocols were administered as part of a larger study investigating treatment for speech and language deficits in PPA. Participants with semantic (n=10) and logopenic (n=11) PPA received lexical retrieval treatment and individuals with nonfluent/agrammatic PPA (n=10) received video-implemented script training for aphasia designed to promote speech production and fluency. Treatment was administered via teletherapy for approximately half of the participants receiving each intervention. Treatment outcomes and performance on standardized tests were assessed at pre-treatment and post-treatment, as well as 3, 6, and 12 months post-treatment.

resultsOverall, both treatment approaches resulted in significant gains for primary outcome measures. Critically, comparison of in-person and teletherapy groups revealed comparable outcomes. Generalization to untrained targets and tasks and maintenance of treatment-induced gains were also comparable for traditional vs teletherapy participants.

conclusionOverall, treatment outcomes were largely equivalent for individuals receiving treatment via teletherapy vs traditional, in-person delivery. Results support the application of teletherapy for administering restitutive interventions to individuals with mild-to-moderate PPA. Potential implications for using teletherapy in the treatment of cognitive-linguistic and motoric impairments in other disorders and suggestions for administering treatment via telemedicine are discussed.

Indexed as

TelemedicineAgedAphasia, Primary ProgressiveFeasibility StudiesFemaleHealth Services AccessibilityHumansLanguageMaleMiddle AgedSpeech TherapyTreatment Outcomelexical retrieval treatmentPPAscript trainingtelemedicinetelepracticetelerehabilitation

Identifiers

PMID30880927
PMCPMC6394239
OpenAlexW2917024132

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.