ArticleClinical interventions in aging2019
Modified frailty as a novel factor in predicting the response to cardiac resynchronization in the elderly population.
Article in Clinical interventions in aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Association between frailty and adverse outcomes after cardiac resynchronization therapy: a systematic review and meta-analysis.European geriatric medicine · 2025Pooled it
- Outcomes following cardiac resynchronisation therapy in older people.Age and ageing · 2023Article
- Predictors of Early Cardiac Implantable Electronic Device Lead Dislodgement in the Elderly.International journal of environmental research and public health · 2022Article
- Frailty Syndrome in Older Adults with Cardiovascular Diseases-What Do We Know and What Requires Further Research?International journal of environmental research and public health · 2022Review
- A Novel and Simple Exercise Test Parameter to Assess Responsiveness to Cardiac Resynchronization Therapy.Diagnostics (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe response to cardiac resynchronization therapy (CRT) is an important element of the treatment of advanced heart failure, especially in the geriatric population. The aim of the study was to examine the impact of frailty syndrome on the response to treatment with CRT.
methodsTwo hundred and forty-six patients of 60 years or older (aged 73.35±6.95; 22.4% women) with an implanted CRT were included in this single-center prospective study. There was a 12-month follow-up. The Tilburg Frailty Indicator was used to determine frailty (5 or more points). The response to CRT was evaluated based on an analysis of clinical criteria.
resultsOne hundred and sixty-nine of 246 (68.9%) patients were found to be clinical CRT responders. Frailty syndrome was recognized in 173 (70.32%). There were 63.0% responders in the frailty-affected group, whereas there were statistically more responders (79.5%) in the robust group (
conclusionFrailty is a novel independent factor that can be used to predict the clinical response to CRT in the elderly population. Modifying the level of recognition in the Tilburg Frailty Indicator can improve the prediction of a response to CRT.
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Registered trials
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