Evidence map›Paper›PMID 30880853›Full record

ArticleComputational statistics & data analysis2019

Covariance-Insured Screening.

Kevin He, Jian Kang, Hyokyoung G Hong, Ji Zhu, Yanming Li, Huazhen Lin, Han Xu, Yi Li

Abstract read
In one paragraph

Article in Computational statistics & data analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kevin HeDepartment of Biostatistics, School of Public Health, University of Michigan.
Jian KangDepartment of Biostatistics, School of Public Health, University of Michigan.
Hyokyoung G HongDepartment of Statistics and Probability, Michigan State University.
Ji ZhuDepartment of Statistics, University of Michigan.
Yanming LiDepartment of Biostatistics, School of Public Health, University of Michigan.
Huazhen LinSchool of Statistics, Southwestern University of Finance and Economics.
Han XuDepartment of Statistics, University of Michigan.
Yi LiDepartment of Biostatistics, School of Public Health, University of Michigan.

Funding

The Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2M
Cutting Edge Survival Methods for Epidemiological DataR01AG056764 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI NAN, BIN · 2018 to 2021
$1.3M
Functional Regression and Subgroup Analysis for Asynchronous Longitudinal Data.R21AG058198 · NIA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LI, YEHUA, LI, YI · 2018 to 2019
$422k
NCI NIH HHS U01 CA209414NIA NIH HHS R01 AG056764NIA NIH HHS R21 AG058198
6 · The paper itself

Abstract

Modern bio-technologies have produced a vast amount of high-throughput data with the number of predictors far greater than the sample size. In order to identify more novel biomarkers and understand biological mechanisms, it is vital to detect signals weakly associated with outcomes among ultrahigh-dimensional predictors. However, existing screening methods, which typically ignore correlation information, are likely to miss weak signals. By incorporating the inter-feature dependence, a covariance-insured screening approach is proposed to identify predictors that are jointly informative but marginally weakly associated with outcomes. The validity of the method is examined via extensive simulations and a real data study for selecting potential genetic factors related to the onset of multiple myeloma.

Indexed as

Covariance-insured screeningDimensionality reductionHigh-dimensional dataVariable selection

Identifiers

PMID30880853
PMCPMC6414211

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.