Evidence map›Paper›PMID 30880502›Full record

ReviewExpert opinion on biological therapy2019

Bioengineering and regeneration of gastrointestinal tissue: where are we now and what comes next?

Elie Zakhem, Shreya Raghavan, Riley A Suhar, Khalil N Bitar

Abstract readReview
In one paragraph

Review in Expert opinion on biological therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elie Zakhema Wake Forest Institute for Regenerative Medicine , Wake Forest School of Medicine , Winston Salem , NC , USA.
Shreya Raghavanc Department of Materials Science and Engineering , University of Michigan , Ann Arbor , MI , USA.
Riley A Suhard Department of Materials Science and Engineering , Stanford University , Stanford , CA , USA.
Khalil N Bitara Wake Forest Institute for Regenerative Medicine , Wake Forest School of Medicine , Winston Salem , NC , USA.

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
BioSphincter to Treat Fecal Incontinence. Phase 1/2 Clinical Trial. SBIR Phase IIBR44DK105593 · NIDDK · CELLF-BIO INC · PI BITAR, KHALIL N · 2018 to 2021
$4.1M
Implantation of Bioengineered Intrinsically Innervated Internal Anal Sphincter (BioSphincter) to Treat Fecal IncontinenceR42DK105593 · NIDDK · CELLF-BIO INC · PI BITAR, KHALIL N · 2015 to 2017
$1.4M
NIDCR NIH HHS T32 DE007057NIDDK NIH HHS R42 DK105593NIDDK NIH HHS R44 DK105593
6 · The paper itself

Abstract

introductionThe field of tissue engineering and regenerative medicine has been applied to the gastrointestinal (GI) tract for a couple decades. Several achievements have been accomplished that provide promising tools for treating diseases of the GI tract. AREAS COVERED: The work described in this review covers the traditional aspect of using cells and scaffolds to replace parts of the tract. Several studies investigated different types of biomaterials and different types of cells. A more recent approach involved the use of gut-derived organoid units that can differentiate into all gut cell layers. The most recent approach introduced the use of organ-on-a-chip concept to understand the physiology and pathophysiology of the GI system. EXPERT OPINION: The different approaches tackle the diseases of the GI tract from different perspectives. While all these different approaches provide a promising and encouraging future for this field, the translational aspect is yet to be studied.

Indexed as

RegenerationTissue EngineeringGastrointestinal TractHumansRegenerative MedicineStem CellsStem Cell TransplantationTissue ScaffoldsbiomaterialsGastrointestinal tractorganoidsorgan-on-a-chipscaffolds

Identifiers

PMID30880502
PMCPMC6534476

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.