ArticleJournal of diabetes science and technology2019
Evaluating the Impact of Human Factors and Pen Needle Design on Insulin Pen Injection.
Article in Journal of diabetes science and technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Optimising Insulin Injection Techniques to Improve Diabetes Outcomes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023Review
- Imaging of large volume subcutaneous deposition using MRI: exploratory clinical study results.Drug delivery and translational research · 2023Article
- Needle Technology for Insulin Administration: A Century of Innovation.Journal of diabetes science and technology · 2023Review
- Novel cannula design improves large volume auto-injection rates for high viscosity solutions.Drug delivery · 2022Article
- Patients' Experience of New Technologies and Digitalization in Diabetes Care in Germany.Journal of diabetes science and technology · 2022Article
- Diabetes Technology Meeting 2021.Journal of diabetes science and technology · 2022Article
- Bruising-An Ignored Issue?Journal of diabetes science and technology · 2022Article
- Population Pharmacokinetics of Cotadutide in Subjects with Type 2 Diabetes.Clinical pharmacokinetics · 2022Article
- Insulin Injection Practices in a Population of Canadians with Diabetes: An Observational Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimited published data exists quantifying the influence of human factors (HF) and pen needle (PN) design on delivery outcomes of pen injection systems. This preclinical in vivo study examines the impact of PN hub design and applied force against the skin during injection on needle penetration depth (NPD).
methodTo precisely locate injection depth, PN injections (20 µl; 2 IU, U-100 volume equivalent) of iodinated contrast agent were administered to the flank of Yorkshire swine across a range of clinically relevant application forces against the skin (0.25, 0.75, 1.25, and 2.0 lbf). The NPD, representing in vivo needle tip depth in SC tissue, from four 32 G × 4 mm PN devices (BD Nano
resultsThe reengineered hub design more closely achieved the 4 mm target NPD with significantly less variability ( P = .006) than commercial posted-hub PN devices across the range of applied injection forces. Calculations of IM (intramuscular) injection risk completed through in silico probability model, using NPD and average human tissue thickness measurements, displayed a commensurate reduction (~2-8x) compared to conventional PN hub designs.
conclusionsQuantifiable differences in injection depth were observed between identical labeled length PN devices indicating that hub design features, coupled with aspects of variable injection technique, may influence injection depth accuracy and consistency. The reengineered hub design may reduce the impact of unintended individual technique differences by improving target injection depth consistency and reducing IM injection potential.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.