Evidence map›Paper›PMID 30880251›Full record

ReviewJournal of molecular and cellular cardiology2019

Cardiovascular inflammation: RNA takes the lead.

Colton R Martens, Shyam S Bansal, Federica Accornero

Open access · greenAbstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Diabetic neuropathy: A NRF2 disease?Journal of diabetes · 2024
    Review
  3. Review
  4. Long Noncoding RNA MALAT1: Salt-Sensitive Hypertension.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Review
  7. Article
  8. The Relationship between Cancer and Paraoxonase 1.Antioxidants (Basel, Switzerland) · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Long Noncoding RNADiabetes · 2021
    Article
  14. Article
  15. An Update on the Role of PCSK9 in Atherosclerosis.Journal of atherosclerosis and thrombosis · 2020
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Colton R MartensDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States.
Shyam S BansalDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States.
Federica AccorneroDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States. Electronic address: Federica.Accornero@osumc.edu.
The Ohio State University · US

Funding

Post-transcriptional regulation of cardiac hypertrophyR01HL136951 · NHLBI · OHIO STATE UNIVERSITY · PI Federica Accornero · 2017 to 2026
$4.7M
Pathological TNFR1 Expressing CD4+ T-cells are Critical for HF progressionR00HL132123 · NHLBI · OHIO STATE UNIVERSITY · PI BANSAL, SHYAM SUNDER · 2018 to 2020
$738k
BEX1 and the control of protein translation in cardiac hypertrophyR00HL121284 · NHLBI · OHIO STATE UNIVERSITY · PI ACCORNERO, FEDERICA · 2016 to 2018
$727k
BEX1 and the control of protein translation in cardiac hypertrophyK99HL121284 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI ACCORNERO, FEDERICA · 2014 to 2015
$262k
Pathological TNFR1 expressing CD4+ T-cells are critical for HF progressionK99HL132123 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BANSAL, SHYAM SUNDER · 2016 to 2017
$243k
NHLBI NIH HHS K99 HL121284NHLBI NIH HHS K99 HL132123NHLBI NIH HHS R00 HL121284NHLBI NIH HHS R00 HL132123NHLBI NIH HHS R01 HL136951
6 · The paper itself

Abstract

Inflammation has recently gained tremendous attention as a key contributor in several chronic diseases. While physiological inflammation is essential to counter a wide variety of damaging stimuli and to improve wound healing, dysregulated inflammation such as in the myocardium and vasculature can promote cardiovascular diseases. Given the high severity, prevalence, and economic burden of these diseases, understanding the factors involved in the regulation of physiological inflammation is essential. Like other complex biological phenomena, RNA-based processes are emerging as major regulators of inflammatory responses. Among such processes are cis-regulatory elements in the mRNA of inflammatory genes, noncoding RNAs directing the production or localization of inflammatory cytokines/chemokines, or pathogenic RNA driving inflammatory responses. In this review, we describe several specific RNA-based molecular mechanisms by which physiological inflammation pertaining to cardiovascular diseases is regulated. These include the role of AU-rich element-containing mRNAs, long non-coding RNAs, microRNAs, and viral RNAs.

Indexed as

AnimalsAU Rich ElementsCardiovascular SystemHumansInflammationModels, BiologicalRNARNA, ViralRNARNA, Viral

Identifiers

PMID30880251
PMCPMC6641543
OpenAlexW2922425625

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.