ArticleCell stem cell2019
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
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Article in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
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Who cites it
39 citing papers in PubMed, 51 citations in OpenAlex.
- Deformability-augmented mesenchymal stem cells post-enucleation for efficient mRNA intervention of pulmonary fibrosis in rodent model.iScience · 2026Article
- Interleukin-12 Supports Self-renewal Division of Mouse Hematopoietic Stem Cells in Polyvinyl Alcohol-Based Culture.Stem cell reviews and reports · 2026Article
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- Transient mechanical activation of the Piezo1 channel facilitates ex vivo expansion of hematopoietic stem cells.Cell research · 2026Article
- NCOA2 promotes the return of hematopoietic stem cells to quiescence after irradiation stress by regulating FOXO3a-dependent mitophagy.HemaSphere · 2026Article
- Nanoengineered 3D culture substrate enables superior persistence and polyclonal engraftment of genetically engineered hematopoietic stem cells.Cell stem cell · 2026Article
- Reconstruction of hematopoietic stem cell nichesMaterials today. Bio · 2025Review
- Targeting leukemic stem cell biomechanics suppresses stemness and enhances NK cell-mediated immunotherapy.Nature communications · 2025Article
- Two genes, one culprit - a functional candidate validation of a SPATA7 deletion in dogs with day blindness/retinal degeneration.PLoS genetics · 2025Article
- A capsular myofibroblastic niche maintains hematopoietic stem cells in the spleen.The EMBO journal · 2025Article
- Hormonally mediated mechanical remodelling of human haematopoietic stem cells enhances their bone-marrow engraftment.Nature biomedical engineering · 2025Article
- Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone.Nature biomedical engineering · 2025Article
- Elastic properties of leukemic cells linked to maturation stage and integrin activation.iScience · 2025Article
- Article
- Loss of PTPN21 disrupted mitochondrial metabolic homeostasis and aggravated experimental pulmonary fibrosis.Respiratory research · 2024Article
- Phosphatase, MgHaematologica · 2024Article
- Unveiling the role of hypoxia-inducible factor 2alpha in osteoporosis: Implications for bone health.World journal of stem cells · 2024Article
- Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.Science advances · 2024Article
- α1,3-fucosylation treatment improves cord blood CD34 negative hematopoietic stem cell navigation.iScience · 2024Article
- Correlating mechanical and gene expression data on the single cell level to investigate metastatic phenotypes.iScience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 2 countries.
Fang NiDivision of Hematology/Oncology, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA.
Wen-Mei YuDivision of Hematology/Oncology, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA.
Xinyi WangDivision of Hematology/Oncology, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA.
Meredith E FayDivision of Hematology/Oncology, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Katherine M YoungParker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Yongzhi QiuDivision of Hematology/Oncology, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Wilbur A LamDivision of Hematology/Oncology, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Todd A SulchekThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Tao ChengState Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Tianjin 300020, China.
David T ScaddenCenter for Regenerative Medicine and MGH Cancer Center, Massachusetts General Hospital, Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Boston, MA 02114, USA.
Cheng-Kui QuDivision of Hematology/Oncology, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Winship Cancer Institute, Children's Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA. Electronic address: cheng-kui.qu@emory.edu.
Children's Healthcare of Atlanta · USEmory University · USGeorgia Institute of Technology · USThe Wallace H. Coulter Department of Biomedical Engineering · USChinese Academy of Medical Sciences & Peking Union Medical College · CNHarvard University · US
Funding
Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David T Scadden · 2017 to 2026
$24.6MGermline mutations of PTPN11 (SHP2) in the stem cell microenvironmentR01HL130995 · NHLBI · EMORY UNIVERSITY · PI QU, CHENG-KUI · 2016 to 2024
$3.3MMetabolic regulation of hematopoietic stem cellsR01DK092722 · NIDDK · EMORY UNIVERSITY · PI QU, CHENG-KUI · 2011 to 2019
$2.5MLabel-free microfluidic enrichment of cancer cells from noncancer cells in ascites fluidR21CA191243 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI MCDONALD, JOHN F, SULCHEK, TODD · 2016 to 2019
$593kNCI NIH HHS R21 CA191243NHLBI NIH HHS P01 HL131477NHLBI NIH HHS R01 HL130995NIDDK NIH HHS R01 DK092722
Abstract
Hematopoietic stem cell (HSC) quiescence is a tightly regulated process crucial for hematopoietic regeneration, which requires a healthy and supportive microenvironmental niche within the bone marrow (BM). Here, we show that deletion of Ptpn21, a protein tyrosine phosphatase highly expressed in HSCs, induces stem cell egress from the niche due to impaired retention within the BM. Ptpn21
Indexed as
HomeostasisAnimalsHematopoietic Stem CellsMiceMice, Inbred C57BLMice, KnockoutPhosphorylationProtein Tyrosine Phosphatases, Non-ReceptorSeptinsStem Cell NicheProtein Tyrosine Phosphatases, Non-ReceptorPtpn21 protein, mouseSept1 protein, mouseSeptinsbiomechanicscytoskeletonhematopoietic stem cellnicheprotein tyrosine phosphatasePtpn21septin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.