ArticleCurrent biology : CB2019
Metabolic Regulation of Developmental Cell Cycles and Zygotic Transcription.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Optimality as a framework for understanding developmental robustness.Trends in cell biology · 2026Review
- Sex-biased transcriptome in in vitro produced bovine early embryos.Cell & bioscience · 2025Article
- GSK3 coordinately regulates mitochondrial activity and nucleotide metabolism in quiescent oocytes.Biology open · 2025Article
- Historic obstacles and emerging opportunities in the field of developmental metabolism - lessons from Heidelberg.Development (Cambridge, England) · 2024Review
- Collective effects of cell cleavage dynamics.Frontiers in cell and developmental biology · 2024Review
- Review
- Article
- The Nuclear-to-Cytoplasmic Ratio: Coupling DNA Content to Cell Size, Cell Cycle, and Biosynthetic Capacity.Annual review of genetics · 2022Review
- Cullin-5 mutants reveal collective sensing of the nucleocytoplasmic ratio in Drosophila embryogenesis.Current biology : CB · 2022Article
- Modeling the role for nuclear import dynamics in the early embryonic cell cycle.Biophysical journal · 2021Article
- Control of tissue development and cell diversity by cell cycle-dependent transcriptional filtering.eLife · 2021Article
- Balancing energy expenditure and storage with growth and biosynthesis during Drosophila development.Developmental biology · 2021Review
- Cell cycle control during early embryogenesis.Development (Cambridge, England) · 2021Article
- Temporal Gradients Controlling Embryonic Cell Cycle.Biology · 2021Review
- The nuclear to cytoplasmic ratio directly regulates zygotic transcription inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio.PLoS biology · 2020Article
- Cellular metabolic reprogramming controls sugar appetite in Drosophila.Nature metabolism · 2020Article
- Chemical Embryology Redux: Metabolic Control of Development.Trends in genetics : TIG · 2020Review
- The neglected part of early embryonic development: maternal protein degradation.Cellular and molecular life sciences : CMLS · 2020Review
- Excess dNTPs Trigger Oscillatory Surface Flow in the Early Drosophila Embryo.Biophysical journal · 2020Article
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9 authors at 3 institutions in 1 country.
Funding
Abstract
The thirteen nuclear cleavages that give rise to the Drosophila blastoderm are some of the fastest known cell cycles [1]. Surprisingly, the fertilized egg is provided with at most one-third of the dNTPs needed to complete the thirteen rounds of DNA replication [2]. The rest must be synthesized by the embryo, concurrent with cleavage divisions. What is the reason for the limited supply of DNA building blocks? We propose that frugal control of dNTP synthesis contributes to the well-characterized deceleration of the cleavage cycles and is needed for robust accumulation of zygotic gene products. In support of this model, we demonstrate that when the levels of dNTPs are abnormally high, nuclear cleavages fail to sufficiently decelerate, the levels of zygotic transcription are dramatically reduced, and the embryo catastrophically fails early in gastrulation. Our work reveals a direct connection between metabolism, the cell cycle, and zygotic transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.