Evidence map›Paper›PMID 30879992›Full record

ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2019

Normal and fibrotic liver parenchyma respond differently to irreversible electroporation.

Chenang Lyu, Maya Lopez-Ichikawa, Boris Rubinsky, Tammy T Chang

Abstract read
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In one paragraph

Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chenang LyuDepartment of Mechanical Engineering, University of California, Berkeley, CA 94720, USA.
Maya Lopez-IchikawaDepartment of Surgery, University of California, San Francisco, CA 94143, USA.
Boris RubinskyDepartment of Mechanical Engineering, University of California, Berkeley, CA 94720, USA.
Tammy T ChangDepartment of Surgery, University of California, San Francisco, CA 94143, USA. Electronic address: tammy.chang@ucsf.edu.
University of California, Berkeley · USUniversity of California, San Francisco · US

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Y. Chen · 1986 to 2026
$30.7M
Pioneering regenerative surgery - Mechanisms of cell death and regeneration in liver treated with non-thermal irreversible electroporation (NTIRE)R21EB024135 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHANG, TAMMY T · 2018 to 2019
$436k
NIBIB NIH HHS R21 EB024135NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

backgroundThe safety and efficacy of irreversible electroporation (IRE) in treating hepatic, biliary, and pancreatic malignancies are active areas of clinical investigation. In addition, recent studies have shown that IRE may enable regenerative surgery and in vivo tissue engineering. To use IRE effectively in these clinical applications, it is important to understand how different tissue microenvironments impact the response to IRE. In this study, we characterize the electrical and histological properties of non-fibrotic and fibrotic liver parenchyma before and after IRE treatment.

methodsElectrical resistivity and histology of fibrotic liver from C57BL/6 mice fed a 0.1% 3,5-diethylcarbonyl-1,4-dihydrocollidine (DDC) diet were compared to those of non-fibrotic liver from matched control mice before and after IRE treatment.

resultsAt baseline, the electrical resistivity of fibrotic liver was lower than that of non-fibrotic liver. Post-IRE, resistivity of non-fibrotic liver declined and then recovered back to baseline with time, correlating with hepatocyte repopulation of the ablated parenchyma without deposition of fibrotic scar. In contrast, resistivity of fibrotic liver remained depressed after IRE treatment, correlating with persistent inflammation.

conclusionNon-fibrotic and fibrotic liver respond to IRE differently. The underlying tissue microenvironment is an important modifying factor to consider when designing IRE protocols for tissue ablation.

Indexed as

AnimalsDisease Models, AnimalElectroporationImmunohistochemistryLiverLiver CirrhosisMaleMiceMice, Inbred C57BLPostoperative Period

Identifiers

PMID30879992
PMCPMC7170179
OpenAlexW2890828076

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.