ArticleNeuron2019
The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits.
Open access · greenAbstract read
In one paragraph
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
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115citing papers in PubMed
8.9field-weighted citation impact, top 1% of its field
What it found
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Who cites it
115 citing papers in PubMed, 201 citations in OpenAlex.
- A pontomesencephalic-mesolimbic circuit modulates activity-based anorexia.Science advances · 2026Article
- Long-term pop music exposure impairs production and reproductive performance in laying hens via neural and oxidative stress pathways.Poultry science · 2026Article
- A hypothalamic circuit links hunger to mesolimbic dopamine to drive feeding.bioRxiv : the preprint server for biology · 2026Article
- Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced weight gain in female mice.Nature communications · 2026Article
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- Primary cilia and neural computation.Journal of biomedical science · 2026Review
- Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
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- GPR75 in glutamatergic neurons regulates body weight.Cell reports · 2026Article
- A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types.Cell reports · 2026Article
- Cellular coding of ingestion in the caudal brainstem.bioRxiv : the preprint server for biology · 2026Article
- Individual paraventricular hypothalamic GLP-1R neurons track ingestion across energy states.iScience · 2025Article
- A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types.Research square · 2025Article
- A hypothalamic circuit for anticipating future changes in energy balance.bioRxiv : the preprint server for biology · 2025Article
- Glucagon-Like Peptide 1 (GLP-1) Action on Hypothalamic Feeding Circuits.Endocrinology · 2025Review
- Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism.Cell metabolism · 2025Article
- ParabrachialiScience · 2025Article
- Uncovering the role of Gpr45 in obesity regulation.Molecular metabolism · 2025Article
- Epigenome Engineering Using dCas Systems for Biomedical Applications and Biotechnology: Current Achievements, Opportunities and Challenges.International journal of molecular sciences · 2025Review
- State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis.Nature metabolism · 2025Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Monica M LiDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Joseph C MadaraDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Jennifer S StegerDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Michael J KrashesDiabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Nina BalthasarDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
John N CampbellDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Jon M ReschDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Nicholas J ConleyDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Alastair S GarfieldDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK. Electronic address: agarfield@rhythmtx.com.
Bradford B LowellDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02215, USA. Electronic address: blowell@bidmc.harvard.edu.
Harvard University · USBeth Israel Deaconess Medical Center · USNational Institute of Diabetes and Digestive and Kidney Diseases · US
Funding
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0MThe routing of hunger/satiety information by the parabrachial nucleus (PBN)R01DK075632 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BRADFORD B LOWELL · 2006 to 2026
$8.1MAGRP NEURONS. NMDARs, Spines, Source of Excitatory Input and Downstream EffectorsR01DK096010 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2012 to 2024
$7.2MNeurocircuitry Underlying Leptin Regulation of Energy BalanceR01DK089044 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2010 to 2023
$6.0MInvestigating the interaction of motivational systemsZIADK075090 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7MProbing neural circuits underlying satietyZIADK075087 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7MInvestigating addictive/compulsive feeding behaviorZIADK075088 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7MGlutamatergic Neurons in the Arcuate Nucleus (ARC) and Regulation of SatietyR01DK111401 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2016 to 2020
$2.2MAgRP neurocircuitry regulating energy expenditureF32DK103387 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RESCH, JON · 2014 to 2017
$159kAmerican Heart Association-American Stroke Association 14POST20100011NIDDK NIH HHS F32 DK103387NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK075632NIDDK NIH HHS R01 DK089044NIDDK NIH HHS R01 DK096010NIDDK NIH HHS R01 DK111401
Abstract
SIM1-expressing paraventricular hypothalamus (PVH) neurons are key regulators of energy balance. Within the PVH
Indexed as
Agouti-Related ProteinAnimalsArcuate Nucleus of HypothalamusBasic Helix-Loop-Helix ProteinsEnergy MetabolismEnkephalinsFeeding BehaviorLocus CoeruleusMiceNeuronsObesityParabrachial NucleusParaventricular Hypothalamic NucleusProtein PrecursorsReceptor, Melanocortin, Type 4Repressor ProteinsAgouti-Related ProteinAgrp protein, mouseBasic Helix-Loop-Helix ProteinsEnkephalinsMC4R protein, mousepreproenkephalinProtein PrecursorsReceptor, Melanocortin, Type 4Repressor ProteinsSim1 protein, mouse
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.