ArticleThe Journal of pediatrics2019
Risk Factors for Complications in Children with Staphylococcus aureus Bacteremia.
Article in The Journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- The prevalence and risk factors of methicillin-resistant Staphylococcus aureus among pediatric populations: a systematic review and meta-analysis.European journal of pediatrics · 2024Pooled it
- Contemporary Trends in Global Mortality of Sepsis Among Young Infants Less Than 90 Days: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Risk of Infective Endocarditis in Pediatric Staphylococcal Bacteremia: A 20-Year Cohort Study.The Pediatric infectious disease journal · 2026Article
- S. aureus infections in hospitalized children with hematological, hepatological or kidney diseases over a 16-year period at a tertiary care hospital in Sweden: a retrospective observational study.Italian journal of pediatrics · 2026Observational
- Case Report: Progressive limb necrosis as a portal to multifocal osteomyelitis in pediatric septic shock: a tissue-oriented management paradigm.Frontiers in pediatrics · 2026Article
- Investigating Different Clinical Manifestations ofChildren (Basel, Switzerland) · 2025Article
- Community-acquired Staphylococcus aureus bacteremia in healthy children-13 years of experience in a pediatric tertiary center.European journal of pediatrics · 2025Article
- Risk Factors for Persistent Staphylococcus aureus Bacteremia in Children.The Pediatric infectious disease journal · 2024Observational
- Clinical Outcomes of Oral Antibiotic Switch in Children with Staphylococcus aureus Bacteremia.Turkish archives of pediatrics · 2024Article
- Rapid Visual Detection of Methicillin-ResistantMicroorganisms · 2024Article
- [Screening of pathogenic molecular markers ofZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- Predictive models for sepsis in children with Staphylococcus aureus bloodstream infections: a retrospective cohort study.BMC pediatrics · 2023Article
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- Antimicrobial resistance profile of methicillin-resistantFrontiers in cellular and infection microbiology · 2023Article
- Management and Prevention of Staphylococcus aureus Infections in Children.Infectious disease clinics of North America · 2022Review
- A Multicenter Analysis of Changes in Pediatric Antibiotic Susceptibilities AmongThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Reduced Vancomycin Susceptibility, MRSA and Treatment Failure in Pediatric Staphylococcus aureus Bloodstream Infections.The Pediatric infectious disease journal · 2021Article
- Acute infectious osteomyelitis in children: new treatment strategies for an old enemy.World journal of pediatrics : WJP · 2020Review
- Paradoxical Antibiotic Effect of Ampicillin: Use of a Population Pharmacokinetic Model to Evaluate a Clinical Correlate of the Eagle Effect in Infants With Bacteremia.The Pediatric infectious disease journal · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo determine risk factors for complications in children with Staphylococcus aureus (S aureus) bacteremia, including methicillin resistance. STUDY
designSingle center, retrospective cohort study of children ≤18 years of age hospitalized with S aureus bacteremia. We compared clinical characteristics and outcomes between those with methicillin-sensitive S aureus (MSSA) and methicillin-resistant S aureus (MRSA) bacteremia. Multivariate regression models identified risk factors associated with developing complications and with longer duration of bacteremia.
resultsWe identified 394 episodes of S aureus bacteremia, 279 (70.8%) with MSSA, and 115 (29.2%) with MRSA. Primary site of infection was catheter-related in 34%, musculoskeletal in 30%, skin/soft tissue in 10.2%, pneumonia in 6.4%, and endovascular in 6.6%. Eight children (2.0%) died within 30 days because of S aureus bacteremia, 15 (3.5%) had recurrence within 30 days, and 38 (9.6%) had complications including septic emboli or a metastatic focus of infection. Methicillin resistance was associated with development of a complication (aOR 3.31; 95% CI 1.60-6.85), and catheter-related infections were less likely to be associated with a complication (aOR 0.40; 95% CI 0.15-1.03). In a Poisson regression analysis on duration of bacteremia, methicillin resistance, musculoskeletal infection, endovascular infection, black race, and delayed intervention for source control were significantly associated with longer duration of bacteremia.
conclusionsIn this cohort of children with S aureus bacteremia, MRSA infections ere associated with longer duration of bacteremia and a higher likelihood of complications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.