Evidence map›Paper›PMID 30879609›Full record

ArticleThe American journal of cardiology2019

Medication-Taking Behaviors and Perceptions Among Adults With Heart Failure (from the REasons for Geographic And Racial Differences in Stroke Study).

Matthew T Mefford, Alysse Sephel, Melissa K Van Dyke, Ligong Chen, Raegan W Durant, Todd M Brown, Matthew Fifolt, Juan Maya, Parag Goyal, Monika M Safford and 1 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in The American journal of cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Matthew T MeffordUniversity of Alabama at Birmingham, Birmingham, Alabama.
Alysse SephelUniversity of Alabama at Birmingham, Birmingham, Alabama.
Melissa K Van DykeGSK Research & Development, Collegeville, Pennsylvania.
Ligong ChenUniversity of Alabama at Birmingham, Birmingham, Alabama.
Raegan W DurantUniversity of Alabama at Birmingham, Birmingham, Alabama.
Todd M BrownUniversity of Alabama at Birmingham, Birmingham, Alabama.
Matthew FifoltUniversity of Alabama at Birmingham, Birmingham, Alabama.
Juan MayaAmgen Inc., Thousand Oaks, California.
Parag GoyalWeill Cornell Medicine, New York, New York.
Monika M SaffordWeill Cornell Medicine, New York, New York.
Emily B LevitanUniversity of Alabama at Birmingham, Birmingham, Alabama. Electronic address: elevitan@uab.edu.
University of Alabama at Birmingham · USCornell University · USAmgen (United States) · USGlaxoSmithKline (United States) · USUniversity of Alabama at Birmingham Hospital · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
REGARDS - MI StudyR01HL080477 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2006 to 2020
$11.6M
REasons for Geographic And Racial Differences in Stroke-Myocardial Infarction-4 (REGARDS-MI-4)R01HL165452 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2022 to 2025
$8.3M
UAB Health Services Research (HSR) Training ProgramT32HS013852 · AHRQ · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEVITAN, EMILY B, MUGAVERO, MICHAEL J · 2003 to 2024
$8.0M
Impact of Polypharmacy on Rehospitalization in Older Adults with Heart FailureR03AG056446 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI GOYAL, PARAG · 2017 to 2018
$265k
AHRQ HHS T32 HS013852NHLBI NIH HHS R01 HL080477NHLBI NIH HHS R01 HL165452NIA NIH HHS L30 AG060521NIA NIH HHS R03 AG056446NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

Medication regimens in adults with heart failure (HF) are complex which can complicate patient adherence. Individuals with HF frequently use beta blockers (BBs) for multiple indications, including hypertension and HF, but BBs can have significant side effects that may affect their use. We examined medication-taking behaviors and perceptions in individuals with HF with a particular focus on BBs. A mailed survey on medication use was administered to US adults with HF enrolled in the REasons for Geographic And Racial Differences in Stroke study. Among 518 respondents, 357 (69%) reported taking a BB. Nearly half (42%) reported taking ≥10 medications per day. However, 45% indicated that they did not miss any days taking medications, and over 85% reported willingness to take additional medications to prevent further healthcare encounters. Participants' perceptions of BB symptoms varied, but 56% of those who reported experiencing symptoms did not discuss this with their healthcare providers. Adults who experienced HF hospitalization had higher odds of reporting taking BBs to treat HF (odds ratio 1.51, 95% confidence interval 1.19, 1.91). Adults with hypertension were also likely to report taking BBs to treat high blood pressure (odds ratio 2.42, 95% confidence interval 1.79, 3.26). In conclusion, despite extensive medication regimens, individuals with HF were willing to take additional medications for their disease. Participant recognition of BB use for treating HF and co-morbidities was high, yet many do not report side effects to healthcare providers. In conclusion, better understanding of patients' medication-taking behaviors and perceptions may facilitate optimization of HF treatments.

Indexed as

Drug MonitoringEthnicityPerceptionAdrenergic beta-AntagonistsAgedAged, 80 and overFemaleHeart FailureHumansIncidenceMaleMiddle AgedStrokeStroke VolumeUnited StatesAdrenergic beta-Antagonists

Identifiers

PMID30879609
PMCPMC6488419
OpenAlexW2918080594

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.