ArticleStroke2019
Differential Impact of Risk Factors on Stroke Occurrence Among Men Versus Women in West Africa.
Article in Stroke, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Knowledge on hypertension among hypertensive stroke survivors in Ghana: A cross-sectional, multicenter study.Equity neuroscience · 2026Article
- Charting neuroethics discourse in Africa: A scoping review of ethical issues of neuroscience research in Africa.IBRO neuroscience reports · 2025Article
- Demographic Disparities in Stroke Occurrence: Insights From an Integrative Review of Emerging Trends.Brain and behavior · 2025Review
- Population-based stroke risk profile from a West-African community.eNeurologicalSci · 2023Article
- Knowledge and perspectives of community members on risk assessment for stroke prevention using mobile health approaches in Nigeria.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023Article
- Spatial and temporal trends of overweight/obesity and tobacco use in East Africa: subnational insights into cardiovascular disease risk factors.International journal of health geographics · 2023Article
- Association of Psychosocial Stress With Risk of Acute Stroke.JAMA network open · 2022Article
- Key determinants of long-term post-stroke mortality in Ghana.Journal of the neurological sciences · 2022Article
- Neurological disorders encountered at an out-patient clinic in Ghana's largest medical center: A 16-year review.eNeurologicalSci · 2021Article
- Frequency and factors associated with post-stroke seizures in a large multicenter study in West Africa.Journal of the neurological sciences · 2021Article
- Factors associated with hypertension among stroke-free indigenous Africans: Findings from the SIREN study.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- The Relative Contribution of Plasma Homocysteine Levels vs. Traditional Risk Factors to the First Stroke: A Nested Case-Control Study in Rural China.Frontiers in medicine · 2021Article
- Risk factors, clinical outcomes and predictors of stroke mortality in Sierra Leoneans: A retrospective hospital cohort study.Annals of medicine and surgery (2012) · 2020Article
- Apparent Treatment Resistant Hypertension Among Stroke Survivors in Ghana.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020Article
- Antecedent febrile illness and occurrence of stroke in West Africa: The SIREN study.Journal of the neurological sciences · 2020Article
- Frequency and factors linked to refractory hypertension among stroke survivors in Ghana.Journal of the neurological sciences · 2020Article
- Prevalence and predictors of statin utilization among patient populations at high vascular risk in Ghana.Journal of the neurological sciences · 2020Article
- Low blood pressure levels & incident stroke risk among elderly Ghanaians with hypertension.Journal of the neurological sciences · 2020Article
- Spatial Co-Clustering of Cardiovascular Diseases and Select Risk Factors among Adults in South Africa.International journal of environmental research and public health · 2020Article
- Vascular-brain Injury Progression after Stroke (VIPS) study: concept for understanding racial and geographic determinants of cognitive decline after stroke.Journal of the neurological sciences · 2020Review
Corrections and comments
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Authors and funding
27 authors at 16 institutions in 3 countries.
Funding
Abstract
Background and Purpose- The interplay between sex and the dominant risk factors for stroke occurrence in sub-Saharan Africa has not been clearly delineated. We compared the effect sizes of risk factors of stroke by sex among West Africans. Methods- SIREN study (Stroke Investigative Research and Educational Networks) is a case-control study conducted at 15 sites in Ghana and Nigeria. Cases were adults aged >18 years with computerized tomography/magnetic resonance imaging confirmed stroke, and controls were age- and sex-matched stroke-free adults. Comprehensive evaluation for vascular, lifestyle, and psychosocial factors was performed using validated tools. We used conditional logistic regression to estimate odds ratios and reported risk factor specific and composite population attributable risks with 95% CIs. Results- Of the 2118 stroke cases, 1193 (56.3%) were males. The mean±SD age of males was 58.1±13.2 versus 60.15±14.53 years among females. Shared modifiable risk factors for stroke with adjusted odds ratios (95% CI) among females versus males, respectively, were hypertension [29.95 (12.49-71.77) versus 16.1 0(9.19-28.19)], dyslipidemia [2.08 (1.42-3.06) versus 1.83 (1.29-2.59)], diabetes mellitus [3.18 (2.11-4.78) versus 2.19 (1.53-3.15)], stress [2.34 (1.48-3.67) versus 1.61 (1.07-2.43)], and low consumption of green leafy vegetables [2.92 (1.89-4.50) versus 2.00 (1.33-3.00)]. However, salt intake and income were significantly different between males and females. Six modifiable factors had a combined population attributable risk of 99.1% (98.3%-99.6%) among females with 9 factors accounting for 97.2% (94.9%-98.7%) among males. Hemorrhagic stroke was more common among males (36.0%) than among females (27.6%), but stroke was less severe among males than females. Conclusions- Overall, risk factors for stroke occurrence are commonly shared by both sexes in West Africa favoring concerted interventions for stroke prevention in the region.
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Registered trials
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