ArticleJournal of the American Heart Association2019
Coronary Calcium Characteristics as Predictors of Major Adverse Cardiac Events in Symptomatic Patients: Insights From the CORE 320 Multinational Study.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Urolithiasis, Independent of Uric Acid, Increased Risk of Coronary Artery and Carotid Atherosclerosis: A Meta-Analysis of Observational Studies.BioMed research international · 2020Pooled it
- Opportunistic assessment of abdominal aortic calcification using artificial intelligence (AI) predicts coronary artery disease and cardiovascular events.American heart journal · 2025Article
- Article
- The prognostic value of visual and automatic coronary calcium scoring from low-dose computed tomography-[15O]-water positron emission tomography.European heart journal. Cardiovascular Imaging · 2024Article
- Coronary artery calcification burden, atherogenic index of plasma, and risk of adverse cardiovascular events in the general population: evidence from a mediation analysis.Lipids in health and disease · 2024Article
- Plaque Characteristics Derived from Intravascular Optical Coherence Tomography That Predict Cardiovascular Death.Bioengineering (Basel, Switzerland) · 2024Article
- Coronary artery calcium quantification technique using dual energy material decomposition: a simulation study.The international journal of cardiovascular imaging · 2024Article
- Coronary artery calcium mass measurement based on integrated intensity and volume fraction techniques.Journal of medical imaging (Bellingham, Wash.) · 2023Article
- Automated cardiovascular risk categorization through AI-driven coronary calcium quantification in cardiac PET acquired attenuation correction CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Can Serum Fetuin-A be Used as a Marker for Cardiovascular Involvement in Psoriatic Patients?Journal of psoriasis and psoriatic arthritis · 2023Article
- Performance of visual, manual, and automatic coronary calcium scoring of cardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- The novel HFrontiers in cardiovascular medicine · 2023Article
- Association between plaque localization in proximal coronary segments and MACE outcomes in patients with mild CAC: Results from the EISNER study.American journal of preventive cardiology · 2022Article
- Evolving Role of Calcium Density in Coronary Artery Calcium Scoring and Atherosclerotic Cardiovascular Disease Risk.JACC. Cardiovascular imaging · 2022Review
- Subclinical cardiovascular disease and utility of coronary artery calcium score.International journal of cardiology. Heart & vasculature · 2021Review
- Long-Term Clinical Outcomes of New-Generation Drug-Eluting Stents in Coronary Artery Disease: A Real-World Observational Study.Acta Cardiologica Sinica · 2021Article
- Fully automatic framework for comprehensive coronary artery calcium scores analysis on non-contrast cardiac-gated CT scan: Total and vessel-specific quantifications.European journal of radiology · 2021Article
- Cervicocephalic Spotty Calcium for the Prediction of Coronary Atherosclerosis in Patients With Acute Ischemic Stroke.Frontiers in neurology · 2021Article
- The significance of coronary artery calcium score as a predictor of coronary artery stenosis in individuals referred for CT angiography.Journal of cardiovascular and thoracic research · 2020Article
- Coronary Calcium Characteristics as Predictors of Major Adverse Cardiac Events in Symptomatic Patients: Insights From the CORE 320 Multinational Study.Journal of the American Heart Association · 2019Article
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Authors and funding
16 authors.
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Abstract
Background The predictive value of coronary artery calcium ( CAC ) has been widely studied; however, little is known about specific characteristics of CAC that are most predictive. We aimed to determine the independent associations of Agatston score, CAC volume, CAC area, CAC mass, and CAC density score with major adverse cardiac events in patients with suspected coronary artery disease. Methods and Results A total of 379 symptomatic participants, aged 45 to 85 years, referred for invasive coronary angiography, who underwent coronary calcium scanning and computed tomography angiography as part of the CORE 320 (Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320 Detector Computed Tomography) study, were included. Agatston score, CAC volume, area, mass, and density were computed on noncontrast images. Stenosis measurements were made on contrast-enhanced images. The primary outcome of 2-year major adverse cardiac events (30 revascularizations [>182 days of index catheterization], 5 myocardial infarctions, 1 cardiac death, 9 hospitalizations, and 1 arrhythmia) occurred in 32 patients (8.4%). Associations were estimated using multivariable proportional means models. Median age was 62 (interquartile range, 56-68) years, 34% were women, and 56% were white. In separate models, the Agatston, volume, and density scores were all significantly associated with higher risk of major adverse cardiac events after adjustment for age, sex, race, and statin use; density was the strongest predictor in all CAC models. CAC density did not provide incremental value over Agatston score after adjustment for diameter stenosis, age, sex, and race. Conclusions In symptomatic patients, CAC density was the strongest independent predictor of major adverse cardiac events among CAC scores, but it did not provide incremental value beyond the Agatston score after adjustment for diameter stenosis.
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