Evidence map›Paper›PMID 30879172›Full record

ArticleJournal of neuro-oncology2019

Targeted radioimmunotherapy for embryonal tumor with multilayered rosettes.

Kayleen Bailey, Neeta Pandit-Taskar, John L Humm, Pat Zanzonico, Stephen Gilheeney, Nai-Kong V Cheung, Kim Kramer

Open access · greenAbstract readClinical Trial, Phase I
In one paragraph

Article in Journal of neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. B7-H3 in Brain Malignancies: Immunology and Immunotherapy.International journal of biological sciences · 2023
    Review
  6. Phase 1 study of intraventricularJournal of hematology & oncology · 2022
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Theragnostic Aspects and Radioimmunotherapy in Pediatric Tumors.International journal of molecular sciences · 2020
    Review
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kayleen BaileyDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0002-8193-642X
Neeta Pandit-TaskarDepartment of Radiology (Molecular Imaging and Therapy Service), Memorial Sloan Kettering Cancer Center, New York, NY, USA.
John L HummDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Pat ZanzonicoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Stephen GilheeneyDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA.
Nai-Kong V CheungDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA.
Kim KramerDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA. kramerk@mskcc.org.ORCID http://orcid.org/0000-0002-3803-878X
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeWe explored the use of intraventricular

methodsPatients were enrolled in an IRB approved, phase 1, 3 + 3 dose escalation trial. Patients with CNS disease expressing the antibody target antigen B7-H3 were eligible. We report on a cohort of three patients with ETMR who were enrolled on the study. Three symptomatic children (ages 14 months, 3 and 3.5 years) had large parietal masses confirmed to be B7-H3-reactive ETMR. Patients received 2 mCi

resultsPatients received surgery, focal radiation, and high dose chemotherapy. Patients 1 and 2 received

conclusions

Indexed as

Antibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedCentral Nervous System NeoplasmsIodine RadioisotopesNeoplasms, Germ Cell and EmbryonalBrainChild, PreschoolFatal OutcomeFemaleHumansInfantInjections, IntraventricularMaleRadioimmunotherapyRadiometrySpinal Cord8H9 monoclonal antibodyAntibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedIodine Radioisotopesomburtamab I-131131I-8H9131I-OmburtamabEmbryonal tumor with multilayered rosettesETMRRadioimmunotherapy

Identifiers

PMID30879172
PMCPMC7416633
OpenAlexW2921899029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.