Evidence map›Paper›PMID 30879162›Full record

Observational studyClinical and experimental nephrology2019

Negative impact of proteinuria on circulating myeloid dendritic cells.

Masato Ikeda, Risa Terashima, Taku Yamada, Masahiro Suyama, Shinya Yokote, Masatsugu Nakao, Izumi Yamamoto, Keita Hirano, Hideo Okonogi, Hiroyasu Yamamoto and 1 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical and experimental nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Masato IkedaDivision of Nephrology and Hypertension, Department of Internal Medicine, Katsushika Medical Center, Jikei University School of Medicine, 6-41-2 Katsushika-ku, Tokyo, 125-8506, Japan. aoto-jinnai@jikei.ac.jp.ORCID http://orcid.org/0000-0003-3583-5975
Risa TerashimaDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Taku YamadaDivision of Nephrology and Hypertension, Department of Internal Medicine, Katsushika Medical Center, Jikei University School of Medicine, 6-41-2 Katsushika-ku, Tokyo, 125-8506, Japan.
Masahiro SuyamaDivision of Nephrology and Hypertension, Department of Internal Medicine, Katsushika Medical Center, Jikei University School of Medicine, 6-41-2 Katsushika-ku, Tokyo, 125-8506, Japan.
Shinya YokoteDivision of Nephrology and Hypertension, Department of Internal Medicine, Katsushika Medical Center, Jikei University School of Medicine, 6-41-2 Katsushika-ku, Tokyo, 125-8506, Japan.
Masatsugu NakaoDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Izumi YamamotoDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Keita HiranoDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Hideo OkonogiDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Hiroyasu YamamotoDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Takashi YokooDivision of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Jikei University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA decrease in absolute numbers (abs.) of circulating dendritic cells (DCs) and recruitment into target organs has been reported, but whether the level of proteinuria associates with circulating DC abs. has not been clarified.

methodsWe conducted a cross-sectional study of 210 patients with kidney disease aged 21-96 years who were admitted to our hospital for kidney biopsy in 2007-2010. For accuracy, the level of proteinuria was thoroughly measured by 24-h urine collection from patients in their admitted condition. The abs. of total DCs (tDCs), myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) was measured by three-color fluorescence-activated cell sorting (FACS). Patients were divided into four groups based upon the quartile of each DC abs. and one-way ANOVA, and multivariable-adjusted regression analyses were performed.

resultsQuantile analysis showed that the level of daily proteinuria decreased with increasing blood mDC abs., with mean proteinuria levels (g/day) of 2.45, 1.68, 1.68, 1.10 for those in mDC abs. quartiles ≤ 445, < 686, < 907, ≥ 907 cells/10

conclusionWe first reported that circulating mDC abs. has a negative association with the level of proteinuria.

Indexed as

AdultAgedAged, 80 and overCell CountCross-Sectional StudiesDendritic CellsFemaleGlomerular Filtration RateHumansKidneyKidney DiseasesMaleMiddle AgedMyeloid CellsPredictive Value of TestsPrognosisC-reactive proteinDendritic cellseGFRGenderProteinuria

Identifiers

PMID30879162
PMCPMC6555847
OpenAlexW2921393645

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.