ArticleCurrent genetics2019
Autophagy-related gene ATG7 participates in the asexual development, stress response and virulence of filamentous insect pathogenic fungus Beauveria bassiana.
Article in Current genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Genomic signatures of host-range divergence in the generalist Beauveria bassiana and the specialist Beauveria brongniartii.Molecular genetics and genomics : MGG · 2026Article
- The nonautophagic functions of autophagy-related proteins.Autophagy · 2024Review
- Characterization ofToxins · 2023Article
- Integration of Physiological, Transcriptomic and Metabolomic Reveals Molecular Mechanism ofJournal of fungi (Basel, Switzerland) · 2023Article
- Autophagy-Related Gene 4 Participates in the Asexual Development, Stress Response and Virulence of Filamentous Insect Pathogenic FungusJournal of fungi (Basel, Switzerland) · 2023Article
- Virulence ofInsects · 2023Article
- Divergent Physiological Functions of Four Atg22-like Proteins in Conidial Germination, Development, and Virulence of the Entomopathogenic FungusJournal of fungi (Basel, Switzerland) · 2023Article
- Palmitoyl Transferase FonPAT2-Catalyzed Palmitoylation of the FonAP-2 Complex Is Essential for Growth, Development, Stress Response, and Virulence in Fusarium oxysporum f. sp.Microbiology spectrum · 2023Article
- Comparative Transcriptomic Analyses Reveal the Regulatory Mechanism of Nutrient Limitation-Induced Sporulation ofFoods (Basel, Switzerland) · 2022Article
- Expanding the Biological Role of Lipo-Chitooligosaccharides and Chitooligosaccharides inFrontiers in fungal biology · 2022Article
- Article
- Cloning, Expression Analysis, 20-Hydroxyecdysone Induction, and RNA Interference Study of Autophagy-Related Gene 8 fromInsects · 2020Article
- Conserved Autophagy Pathway Contributes to Stress Tolerance and Virulence and Differentially Controls Autophagic Flux Upon Nutrient Starvation inFrontiers in microbiology · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Autophagy is a sophisticated mechanism for maintaining cellular homeostasis, in which E1-like enzyme (ATG7) controls the activation of ubiquitin-like conjugation system in the autophagy pathway. In the insect pathogenic fungus Beauveria bassiana, a yeast ortholog of ATG7 was identified and functionally analyzed. Ablation of BbATG7 gene blocks the autophagic process under starvation stress. The mutant ΔBbATG7 exhibited impaired growth on the media with chitin as single nitrogen source. On rich media, gene loss did not cause notable effect on vegetative growth, but resulted in a considerable reduction in conidiation (71.6%) and blastospore yield (61.1%) in the mutant. In addition, the ΔBbATG7 mutant displayed increased sensitivity to stress caused by menadione and Congo red. The virulence of ΔBbATG7 mutant was significantly attenuated as indicated in topical and intrahemocoel injection assays. Our study indicates that BbATG7 contributes to B. bassiana virulence via regulating autophagy pathway and playing non-autophagic functions in the infection cycle.
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