ArticleRheumatology (Oxford, England)2019
Expanded circulating peripheral helper T cells in systemic lupus erythematosus: association with disease activity and B cell differentiation.
Article in Rheumatology (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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60 citing papers in PubMed, 98 citations in OpenAlex.
- Article
- Beyond B cell helpers: diverse roles of peripheral helper T cells.International immunology · 2026Review
- Phase-specific polarization of peripheral helper T cells influences immunopathology and viral control in HBV infection.Hepatology international · 2026Article
- Not Only Follicular Helper T-Cells but Also Peripheral Helper T-Cells Expanded Correlate With Disease Severity and B-Cell Differentiation in Graves' Disease.International journal of endocrinology · 2026Article
- Bridging B-cell autoimmunity and oncology: the PD-1/PD-L1 paradox in systemic lupus erythematosus.Frontiers in immunology · 2026Review
- Neuroinflammation: a critical bridge linking peripheral pathology and age-related degeneration in myasthenia gravis.Frontiers in medicine · 2026Review
- Effect of CXCR5, PD-1 and ICOS on B-cell responses and relevance to myasthenia gravis.Clinical & translational immunology · 2026Article
- Function of follicular helper 17 T cells in driving B cells for anti-DNA autoantibody production in patients with SLE.Lupus science & medicine · 2025Article
- Circulating peripheral helper T cells are expanded and associate with disease activity in granulomatosis with polyangiitis.Arthritis research & therapy · 2025Article
- Immune-cell profiling to guide stratification and treatment of patients with rheumatic diseases.Nature reviews. Rheumatology · 2025Review
- Expansion of peripheral helper T cells in the peripheral blood of patients with chronic graft-versus-host disease.Annals of hematology · 2025Article
- Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus.Research square · 2025Article
- Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus.bioRxiv : the preprint server for biology · 2025Article
- Recent Evidence of the Role of CD4JMA journal · 2025Review
- Increased sputum peripheral helper T cells are associated with the severity of rheumatoid arthritis but not with the severity of airway disease.Frontiers in immunology · 2025Article
- Comprehensive and advanced T cell cluster analysis for discriminating seropositive and seronegative rheumatoid arthritis.Frontiers in immunology · 2025Article
- Characterization of systemic lupus erythematosus subtypes using cluster analysis: insights from lymphocyte subpopulations.Clinical rheumatology · 2024Article
- Occurrence and role of Tph cells in various renal diseases.Molecular medicine (Cambridge, Mass.) · 2024Review
- Occurrence and role of Tph cells in various renal diseases.Molecular medicine (Cambridge, Mass.) · 2024Review
- High Interleukin 21 Levels in Patients with Systemic Lupus Erythematosus: Association with Clinical Variables and rs2221903 Polymorphism.Journal of clinical medicine · 2024Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePeripheral helper T (TPH) cells are a recently identified Th cell subset that promotes B cell differentiation and antibody production in inflamed tissues. This study investigated circulating TPH cells to determine their involvement in systemic lupus erythematosus (SLE).
methodsPeripheral blood mononuclear cells collected from SLE patients and healthy individuals were analysed. TPH cells were identified as CD3+CD4+CD45RA-CXCR5- cells with a high expression of PD-1. The frequency, activation status and subsets of TPH cells were evaluated by flow cytometry. The production of IL-21 was assessed by intracellular staining and the association of TPH cells with disease activity and B cell populations was determined.
resultsCirculating TPH cells, identified as CD3+CD4+CD45RA-PD-1highCXCR5- cells were increased in the peripheral blood of SLE patients compared with controls. Circulating TPH cells produced similar amounts of IL-21 compared with follicular Th cells. The expansion and activation of TPH cells were correlated with SLE disease activity. Activated TPH cells, particularly Th1-type TPH cells, were associated with the promotion of B cell differentiation in SLE patients.
conclusionThe association of TPH cells with disease activity suggests the involvement of extrafollicular T-B cell interactions in the pathogenesis of SLE. TPH cells promote autoantibody production in aberrant lymphoid organs and therefore might be a novel therapeutic target in autoantibody-producing disorders.
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