ReviewNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2020
Role of CD8+ T cells in crescentic glomerulonephritis.
Review in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Correlation between urinary soluble CD163 and endocapillary proliferation and fibrinoid necrosis in IgA vasculitis with nephritis.Pediatric nephrology (Berlin, Germany) · 2026Article
- The Src-Family Kinases Hck, Fgr and Lyn Drive Immune Complex-Mediated Glomerulonephritis Through the Syk Tyrosine Kinase.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Enhancement of CD8Journal of translational autoimmunity · 2025Article
- Lymphatic vessels in patients with crescentic glomerulonephritis: association with renal pathology and prognosis.Journal of nephrology · 2024Article
- Glomerular crescents are associated with the risk of type 2 diabetic kidney disease progression: a retrospective cohort study.BMC nephrology · 2024Article
- Bowman's capsule rupture and the Oxford MEST-C score in adult patients with Immunoglobulin a vasculitis nephritis: a single center experience.Annals of medicine · 2023Article
- Urinary isomorphic red blood cells for the prediction of disease severity and renal outcomes in MPO-ANCA-associated vasculitis: a retrospective cohort study.Journal of nephrology · 2023Article
- Metalloporphyrins as Tools for Deciphering the Role of Heme Oxygenase in Renal Immune Injury.International journal of molecular sciences · 2023Review
- Molecular mechanisms governing the progression of nephritis in lupus prone mice and human lupus patients.Frontiers in immunology · 2023Article
- Immunopathology of Renal Tissue in Fatal Cases of Dengue in Children.Pathogens (Basel, Switzerland) · 2022Article
- Review
- Association of Bowman's capsule rupture with prognosis in patients with lupus nephritis.Journal of nephrology · 2022Article
- Article
- Digital Spatial Profiling of Individual Glomeruli From Patients With Anti-Neutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis.Frontiers in immunology · 2022Article
- CD8+ T Cells in GCA and GPA: Bystanders or Active Contributors?Frontiers in immunology · 2021Review
- Conventional Type 1 Dendritic Cells (cDC1) in Human Kidney Diseases: Clinico-Pathological Correlations.Frontiers in immunology · 2021Article
- Narrative Review of Hypercoagulability in Small-Vessel Vasculitis.Kidney international reports · 2020Review
- The glomerular crescent: triggers, evolution, resolution, and implications for therapy.Current opinion in nephrology and hypertension · 2020Review
- TNF-α in T lymphocytes attenuates renal injury and fibrosis during nephrotoxic nephritis.American journal of physiology. Renal physiology · 2020Article
- Clinicopathological features and prognostic analysis of 49 cases with crescentic glomerulonephritis.Experimental and therapeutic medicine · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Crescentic glomerulonephritis (cGN) comprises three main types according to the pathogenesis and immunofluorescence patterns: anti-glomerular basement membrane antibody cGN, vasculitis-associated cGN and post-infectious immune complex cGN. In this brief review of the immune-pathogenesis of cGN, the focus is mainly on the role of CD8+ T cells in the progression of cGN. Under control conditions, Bowman's capsule (BC) provides a protected immunological niche by preventing access of cytotoxic CD8+ T cells to Bowman's space and thereby podocytes. Even in experimental nephrotoxic nephritis, leukocytes accumulate around the glomeruli, but remain outside of BC, as long as the latter remains intact. However, when and where breaches in BC occur, the inflammatory cells can gain access to and destroy podocytes, thus converting cGN into rapidly progressive glomerulonephritis (RPGN). These conclusions also apply to human cGN, where biopsies show that loss of BC integrity is associated with RPGN and progression to end-stage kidney disease. We propose a two-hit hypothesis for the role of cytotoxic CD8+ T cells in the progression of cGN. The initial insult occurs in response to the immune complex formation or deposition, resulting in local capillary and podocyte injury (first hit). The injured podocytes release neo-epitopes, eventually causing T-cell activation and migration to the glomerulus. Upon generation of breaches in BC, macrophages and CD8+ T cells can now gain access to the glomerular space and destroy neo-epitope expressing podocytes (second hit), resulting in RPGN. While further investigation will be required to test this hypothesis, future therapeutic trials should consider targeting of CD8+ T cells in the therapy of progressive cGN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.