Evidence map›Paper›PMID 30878879›Full record

ArticleiScience2019

Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq.

Oh-Joon Kwon, Yiqun Zhang, Yumei Li, Xing Wei, Li Zhang, Rui Chen, Chad J Creighton, Li Xin

Open access · goldAbstract read
In one paragraph

Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Enhanced prostatic Esr1The Journal of pathology · 2024
    Article
  10. Article
  11. Integration Analysis of Single-Cell Multi-Omics Reveals Prostate Cancer Heterogeneity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Role and mechanism of CD90Molecular medicine (Cambridge, Mass.) · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Oh-Joon KwonDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA; Department of Urology, University of Washington, 850 Republican Street, Seattle, WA 98109, USA.
Yiqun ZhangDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Yumei LiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Xing WeiDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX, USA; Department of Urology, University of Washington, 850 Republican Street, Seattle, WA 98109, USA.
Li ZhangDepartment of Urology, University of Washington, 850 Republican Street, Seattle, WA 98109, USA.
Rui ChenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Chad J CreightonDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA; Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Li XinDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA; Department of Urology, University of Washington, 850 Republican Street, Seattle, WA 98109, USA; Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA. Electronic address: xin18@uw.edu.
Baylor College of Medicine · USUniversity of Washington · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
Molecular Mechanisms of Initiation of Benign Prostatic HyperplasiaR01DK107436 · NIDDK · UNIVERSITY OF WASHINGTON · PI XIN, LI · 2016 to 2024
$4.4M
The Prostate Epithelial Cell Lineage HierarchyR01DK092202 · NIDDK · UNIVERSITY OF WASHINGTON · PI XIN, LI · 2011 to 2019
$3.2M
High Throughput Genomic Sequencer at BCM Core FacilityS10OD023469 · OD · BAYLOR COLLEGE OF MEDICINE · PI CHEN, RUI · 2017 to 2017
$600k
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
Acquisition of the Fluidigm system to accelerate functional genomics researchS10OD018033 · OD · BAYLOR COLLEGE OF MEDICINE · PI CHEN, RUI · 2014 to 2014
$396k
NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NIAID NIH HHS P30 AI036211NIDDK NIH HHS R01 DK092202NIDDK NIH HHS R01 DK107436NIH HHS S10 OD018033NIH HHS S10 OD023469
6 · The paper itself

Abstract

We perform a single-cell RNA sequencing analysis to investigate the phenotypic and functional heterogeneity of the adult mouse prostate stromal cells. Our analysis identifies three major cell populations representing the smooth muscle cells and two types of fibroblast cells enriched by Sca-1 and CD90. The Sca-1

Indexed as

Biological SciencesCell BiologyIntegrative Aspects of Cell BiologyMolecular Biology

Identifiers

PMID30878879
PMCPMC6423355
OpenAlexW2918240032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.