ArticleJACC. Cardiovascular imaging2019
Multiparametric Cardiac Magnetic Resonance Imaging Can Detect Acute Cardiac Allograft Rejection After Heart Transplantation.
Article in JACC. Cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Cardiac Magnetic Resonance Imaging Findings in 2954 COVID-19 Adult Survivors: A Comprehensive Systematic Review.Journal of magnetic resonance imaging : JMRI · 2022Pooled it
- Cardiovascular magnetic resonance native TJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Pooled it
- Cardiac magnetic resonance in heart transplant recipients: histological, clinical and cell-free DNA validation.European heart journal. Cardiovascular Imaging · 2025Trial
- Article
- Multiparametric cardiac MRI in the diagnosis of transplant rejection in patients after orthotopic heart transplantation.European radiology · 2026Article
- Non-invasive detection of acute cell-mediated graft rejection in paediatric heart transplant recipients: The role of cardiovascular magnetic resonance.International journal of cardiology. Congenital heart disease · 2026Article
- Abnormal Cardiac Magnetic Resonance Imaging Mapping Parameters in Pediatric Heart Transplant Patients with Elevated Donor-Derived Cell Free DNA.Pediatric cardiology · 2026Article
- Toward a biopsy-free approach: cardiac magnetic resonance T1 mapping for detecting heart transplant rejection.European heart journal. Cardiovascular Imaging · 2026Article
- Role of Cardiovascular Magnetic Resonance in Post-Heart Transplant Surveillance: Integrating Evidence with Prospective Cohort Data.Journal of personalized medicine · 2026Article
- The performance of free-breathing multiparametric SAturation-recovery single-SHot acquisition T1 and T2 mapping in cardiac allograft rejection.The international journal of cardiovascular imaging · 2026Article
- Ultrasound medicine in the era of precision theranostics: Mechanisms, molecular strategies, and clinical translation.Iranian journal of basic medical sciences · 2026Review
- The use of multimodality imaging in heart transplant recipients: a case series.European heart journal. Case reports · 2025Article
- Cardiac magnetic resonance imaging assessment of myocardial disease in children and adolescents.Cardiovascular diagnosis and therapy · 2025Review
- Utilizing cardiac magnetic resonance to assess the sequelae of prior rejection episodes on myocardium and correlation with clinical outcomes.JHLT open · 2025Article
- Left ventricular longitudinal function is reduced but partially compensated by increased radial function after heart transplantation.JHLT open · 2025Article
- Incremental value of multiparametric cardiac magnetic resonance imaging for non-invasive identification of significant acute cardiac allograft rejection: a prospective and biopsy-proven study.European heart journal. Cardiovascular Imaging · 2025Article
- Advancements in noninvasive techniques for transplant rejection: from biomarker detection to molecular imaging.Journal of translational medicine · 2025Review
- Redefining Cardiac Antibody-Mediated Rejection With Donor-Specific Antibodies and Graft Dysfunction.Circulation. Heart failure · 2024Article
- Unveiling the invisible: Is there a role of CMR in biopsy-negative graft dysfunction post-heart transplantation?ESC heart failure · 2024Article
- Advancing Cardiovascular Imaging: The Promise of High-Field-Strength MRI in Coronary Artery Disease Assessment.Radiology · 2024Article
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Authors and funding
14 authors at 1 institution in 2 countries.
Funding
Abstract
objectivesThe purpose of this study was to evaluate the sensitivity of multiparametric cardiac magnetic resonance imaging (CMR) for the detection of acute cardiac allograft rejection (ACAR).
backgroundACAR is currently diagnosed by endomyocardial biopsy, but CMR may be a noninvasive alternative because of its capacity for regional myocardial structure and function characterization.
methodsFifty-eight transplant recipients (mean age 47.0 ± 14.7 years) and 14 control subjects (mean age 47.7 ± 16.7 years) were prospectively recruited from August 2014 to May 2017 and underwent 97 CMR studies (83 transplant recipients, 14 control subjects) for assessment of global left ventricular function and myocardial T2, T1, and extracellular volume fraction (ECV). CMR studies were divided into 4 groups on the basis of biopsy grade: control subjects (n = 14), patients with no ACAR (no history of ACAR; n = 36), patients with past ACAR (history of ACAR; n = 24), and ACAR+ patients (active grade ≥1R ACAR; n = 23).
resultsMyocardial T2 was significantly higher in patients with past ACAR compared with those with no ACAR (51.0 ± 3.8 ms vs. 49.2 ± 4.0 ms; p = 0.02) and in patients with no ACAR compared with control subjects (49.2 ± 4.0 ms vs. 45.2 ± 2.3 ms; p < 0.01). ACAR+ patients demonstrated increased T2 compared with the no ACAR group (52.4 ± 4.7 ms vs. 49.2 ± 4.0 ms, p < 0.01) but not compared with the past ACAR group. In contrast, ECV was significantly elevated in ACAR+ patients compared with transplant recipients without ACAR regardless of history of ACAR (no ACAR: 31.5 ± 3.9% vs. 26.8 ± 3.3% [p < 0.01]; past ACAR: 31.5 ± 3.9% vs. 26.8 ± 4.0% [p < 0.01]). Receiver operating characteristic curve analysis revealed that a combined model of age at CMR, global T2, and global ECV was predictive of ACAR (area under the curve = 0.84).
conclusionsThe combination of CMR-derived myocardial T2 and ECV has potential as a noninvasive tissue biomarker for ACAR. Larger studies during acute ACAR are needed for continued development of multiparametric CMR for transplant recipient surveillance.
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