ArticleBehavioural brain research2019
The attention set-shifting test is sensitive for revealing sex-based impairments in executive functions following developmental lead exposure in rats.
Article in Behavioural brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Under or Absent Reporting of Light Stimuli in Testing of Anxiety-Like Behaviors in Rodents: The Need for Standardization.Frontiers in molecular neuroscience · 2022Pooled it
- The dynamic strategy shifting task: Optimisation of an operant task for assessing cognitive flexibility in rats.Frontiers in psychiatry · 2024Article
- Influence ofInternational journal of environmental research and public health · 2023Article
- Taurine-Derived Compounds Produce Anxiolytic Effects in Rats Following Developmental Lead Exposure.Advances in experimental medicine and biology · 2022Article
- Developmental Lead Exposure in Rats Causes Sex-Dependent Changes in Neurobiological and Anxiety-Like Behaviors that Are Improved by Taurine Co-treatment.Advances in experimental medicine and biology · 2022Article
- Influences of Taurine Pharmacodynamics and Sex on Active Avoidance Learning and Memory.Advances in experimental medicine and biology · 2022Article
- In Vivo Sex-Dependent Effects of Perinatal PbAdvances in experimental medicine and biology · 2022Article
- Low-level Lead Exposure Impairs Fronto-executive Functions: A Call to Update the DSM-5 with Lead Poisoning as a Neurodevelopmental Disorder.Psychology & neuroscience · 2020Article
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4 authors.
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Abstract
The literature on lead (Pb) exposure has focused in large part on hippocampal-based learning and memory deficits, although frontoexecutive dysfunctions are known to exist in Pb-exposed humans. This study examined the effects of perinatal (PERI) and early postnatal (EPN) developmental low-level Pb-exposures in rats on frontoexecutive functions, using the Attention Set-Shift Test (ASST). Control males and females performed the ASST similarly. Male EPN rats had difficulty with simple discrimination (SD) of odors and failed to complete the compound discrimination (CD) stage of the ASST. All other Pb-exposed rats completed the training and testing. Male PERI rats performed worse on the SD, intradimensional (ID), and intradimensional-reversal (ID-Rev) ASST stages when compared to male Control rats. Female EPN rats performed similar to Controls on the ID-Rev rats, whereas PERI rats performed better the trials-to-criterion on the ID-Rev than EPN and Control rats. Pb-exposed female rats had significant difficulty performing the ED/ED-Rev stages, with the number of trials-to-criterion double that required by Pb-exposed and Control male rats and Control female rats. Together, the ASST results showed that developmental Pb-exposure induces frontoexecutive dysfunction that persists into adulthood, with different sex-based vulnerabilities dependent upon the time-period of neurotoxicant exposure.
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