ArticleJournal of autoimmunity2019
Elevated autoimmunity in residents living near abandoned uranium mine sites on the Navajo Nation.
Article in Journal of autoimmunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 46 citations in OpenAlex.
- Characterization of Carcinogenic and Non-Carcinogenic Metal(loid)s in Water Within a Uranium-Mining-Impacted Region in Northwestern New Mexico, USA.International journal of environmental research and public health · 2026Article
- Discovery of uranium content in breastmilk and assessment of associated health risks for mothers and infants in Bihar, India.Scientific reports · 2025Article
- A multidimensional study on the effects of Abelmoschus esculentus (L.) Moench extract in uranyl acetate-exposed Allium cepa L.Scientific reports · 2025Article
- Environmental Risk Factors for Systemic Lupus Erythematosus Through the Lens of Social Determinants of Health.Arthritis care & research · 2025Review
- Zinc as a Mechanism-Based Strategy for Mitigation of Metals Toxicity.Current environmental health reports · 2025Review
- Comparison of circulating and excreted metals and of autoimmunity between two Great Plains Tribal communities.Journal of autoimmunity · 2024Article
- Single Cell Analysis of Human Colonoids Exposed to Uranium-Bearing Dust.Environmental health perspectives · 2024Article
- US drinking water quality: exposure risk profiles for seven legacy and emerging contaminants.Journal of exposure science & environmental epidemiology · 2024Review
- Origin Stories of the 'Grants Uranium District' in Northwestern New Mexico: Archives, Memoirs, and Exploratory Boreholes in the Production of Geological Regions.Engaging science, technology, and society · 2024Article
- Preterm Birth and Metal Mixture Exposure among Pregnant Women from the Navajo Birth Cohort Study.Environmental health perspectives · 2023Article
- Serum autoantibodies and exploratory molecular pathways in rural miners: A pilot study.Journal of translational autoimmunity · 2023Article
- Metal mixture exposures and multiplexed autoantibody screening in Navajo communities exposed to uranium mine wastes.Journal of translational autoimmunity · 2023Article
- Environmental uranium exposures and cytokine profiles among mother-newborn baby pairs from the Navajo Βirth Cohort Study.Toxicology and applied pharmacology · 2022Article
- Chronic Community Exposure to Environmental Metal Mixtures Is Associated with Selected Cytokines in the Navajo Birth Cohort Study (NBCS).International journal of environmental research and public health · 2022Article
- The immunotoxicity of natural and depleted uranium: From cells to people.Toxicology and applied pharmacology · 2022Review
- Systemic Lupus Erythematosus Risk: The Role of Environmental Factors.Rheumatic diseases clinics of North America · 2022Review
- Radioactive releases from the nuclear power sector and implications for child health.BMJ paediatrics open · 2022Review
- The fate of inhaled uranium-containing particles upon clearance to gastrointestinal tract.Environmental science. Processes & impacts · 2022Article
- Environmental and occupational health on the Navajo Nation: a scoping review.Reviews on environmental health · 2022Article
- The role of environmental exposures and gene-environment interactions in the etiology of systemic lupus erythematous.Journal of internal medicine · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Specific autoantibodies were assessed among residents of the Navajo Nation in New Mexico chronically exposed to metal mixtures from uranium mine wastes and in drinking water supplies. Age and the extent of exposure to legacy waste from 100 abandoned uranium mine and mill sites were associated with antibodies to denatured DNA, previously known to be an early indicator of medication-induced autoimmunity. Surprisingly, autoantibodies to native DNA and/or chromatin were also linked to environmental exposure, specifically uranium consumption through drinking water for both men and women, while urinary arsenic was negatively associated with these autoantibodies in women. These findings suggest that contaminants derived from uranium mine waste enhanced development of autoantibodies in some individuals, while arsenic may be globally immunosuppressive with gender-specific effects. Specific autoantibodies may be a sensitive indicator of immune perturbation by environmental toxicants, an adverse effect not considered in current drinking water standards or regulatory risk assessment evaluations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.