ArticleBosnian journal of basic medical sciences2019
Epidemiology and mechanism of drug resistance of Mycoplasma pneumoniae in Beijing, China: A multicenter study.
Article in Bosnian journal of basic medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Association between point mutations of macrolide-resistantFrontiers in pharmacology · 2025Pooled it
- Wuhu decoction combined with azithromycin for treatment ofFrontiers in pharmacology · 2024Pooled it
- Post-pandemic surge ofJournal of clinical microbiology · 2026Article
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- Epidemiology of acute respiratory infections in children in Pudong, Shanghai: analysis of seven respiratory test results from 2018 to 2023.Virology journal · 2026Article
- Epidemiological trends, antimicrobial resistance, and genetic mutations ofOpen medicine (Warsaw, Poland) · 2026Article
- Epidemiological analysis of six common respiratory pathogen infections in children in Chengdu from 2022 to 2024.Frontiers in pediatrics · 2026Article
- Comprehensive study of community acquiredWorld journal of clinical pediatrics · 2025Article
- Clinical features associated with macrolides resistance of Mycoplasma pneumoniae pneumonia in children: a single-center analysis.BMC infectious diseases · 2025Article
- Short-term air pollution exposure and risk of respiratory pathogen infections: an 11-year case-crossover study in Guangzhou, China.BMC public health · 2025Article
- Epidemiological trends and serological profiles of respiratory pathogens in Guangzhou: an 11-year retrospective study from 2013 to 2023.Journal of thoracic disease · 2025Article
- Development of machine learning-based differential diagnosis model and risk prediction model of organ damage for severe Mycoplasma pneumoniae pneumonia in children.Scientific reports · 2025Article
- Protective immunity induced by a novel P1 adhesin C-terminal anchored mRNA vaccine againstMicrobiology spectrum · 2025Article
- Recent Macrolide Resistance Pattern of Mycoplasma Pneumonia in the World: A Systematic Review and Meta-Analysis.Iranian journal of public health · 2025Review
- Case Report: A neonatal case of severe congenitalFrontiers in pediatrics · 2025Article
- P1 adhesin genotype characteristics ofFrontiers in cellular and infection microbiology · 2025Article
- Predictive value of bronchoscopy combined with CT score for refractory mycoplasma pneumoniae pneumonia in children.BMC pulmonary medicine · 2024Article
- Correlation of DNA load, genotyping, and clinical phenotype ofFrontiers in pediatrics · 2024Article
- Establishment and evaluation of MIRA-qPCR assay for the rapid and sensitively detection ofFuture microbiology · 2024Article
- Influence of non-pharmaceutical interventions on epidemiological characteristics ofFrontiers in microbiology · 2024Article
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycoplasma pneumoniae (M. pneumoniae) is one of the most common causes of community-acquired respiratory tract infections (RTIs). We aimed to investigate the prevalence of M. pneumoniae infection, antibiotic resistance and genetic diversity of M. pneumoniae isolates across multiple centers in Beijing, China. P1 protein was detected by Nested PCR to analyze the occurrence of M. pneumoniae in pediatric patients with RTI. M. pneumoniae isolates were cultured and analyzed by Nested-PCR to determine their genotypes. Broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of antibiotics. Out of 822 children with RTI admitted to 11 hospitals in Beijing, 341 (41.48%) were positive for M. pneumoniae by Nested PCR and 236 (69.21%) samples had mutations in 23S rRNA domain V. The highest proportion of M. pneumoniae positive samples was observed in school-age children (118/190; 62.11%) and in pediatric patients with pneumonia (220/389; 56.56%). Out of 341 M. pneumoniae positive samples, 99 (12.04%) isolates were successfully cultured and the MIC values were determined for 65 M. pneumoniae strains. Out of these, 57 (87.69%) strains were resistant to macrolides, and all 65 strains were sensitive to tetracyclines or quinolones. M. pneumoniae P1 type I and P1 type II strains were found in 57/65 (87.69%) and 8/65 (12.31%) of cultured isolates, respectively. Overall, we demonstrated a high prevalence of M. pneumoniae infection and high macrolide resistance of M. pneumoniae strains in Beijing. School-age children were more susceptible to M. pneumoniae, particularly the children with pneumonia. Thus, establishment of a systematic surveillance program to fully understand the epidemiology of M. pneumoniae is critical for the standardized use of antibiotics in China.
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