Evidence map›Paper›PMID 30877885›Full record

ReviewCurrent opinion in virology2019

Mutually assured destruction: the cold war between viruses and natural killer cells.

Ayad Ali, Ivayla E Gyurova, Stephen N Waggoner

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. NK cells in SARS-CoV-2 infection.Central-European journal of immunology · 2022
    Review
  9. Targeting natural killer cells to enhance vaccine responses.Trends in pharmacological sciences · 2021
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Generation and characterization of anDisease models & mechanisms · 2020
    Article
  16. Article
  17. Article
  18. Review
  19. How I Manage Natural Killer Cell Deficiency.Journal of clinical immunology · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ayad AliCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, United States; Medical Scientist Training Program, University of Cincinnati College of Medicine, United States; Immunology Graduate Training Program, University of Cincinnati College of Medicine, United States.
Ivayla E GyurovaCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, United States; Pathobiology and Molecular Medicine Graduate Program, University of Cincinnati College of Medicine, United States.
Stephen N WaggonerCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, United States; Medical Scientist Training Program, University of Cincinnati College of Medicine, United States; Immunology Graduate Training Program, University of Cincinnati College of Medicine, United States; Pathobiology and Molecular Medicine Graduate Program, University of Cincinnati College of Medicine, United States; Department of Pediatrics, University of Cincinnati College of Medicine, United States. Electronic address: Stephen.Waggoner@cchmc.org.

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Medical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7M
A revolutionary vaccine approach to prevent HIV infection in substance abuseDP1DA038017 · NIDA · CINCINNATI CHILDRENS HOSP MED CTR · PI WAGGONER, STEPHEN N. · 2014 to 2018
$3.9M
NCATS NIH HHS UL1 TR001425NIDA NIH HHS DP1 DA038017NIGMS NIH HHS T32 GM063483
6 · The paper itself

Abstract

Natural killer (NK) cells play a multitude of antiviral roles that are significant enough to provoke viral counterefforts to subvert their activity. As innate lymphocytes, NK cells provide a rapid source of pro-inflammatory antiviral cytokines and bring to bear cytolytic activities that are collectively meant to constrain viral replication and dissemination. Additionally, NK cells participate in adaptive immunity both by shaping virus-specific T-cell responses and by developing adaptive features themselves, including enhanced antibody-dependent effector functions. The relative importance of different functional activities of NK cells are poorly understood, thereby obfuscating clinical use of these cells. Here we focus on opposing efforts of NK cells and viruses to gain tactical superiority during infection.

Indexed as

Immunity, InnateAdaptive ImmunityAnimalsHumansImmune EvasionKiller Cells, NaturalMiceVirus DiseasesVirusesVirus Replication

Identifiers

PMID30877885
PMCPMC6476651

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.