ArticleCerebral cortex (New York, N.Y. : 1991)2019
Dynamic Causal Modeling of the Relationship between Cognition and Theta-alpha Oscillations in Adults with Down Syndrome.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Connection between attention, executive function, episodic memory, and adaptive functioning in young adults with Down syndrome.International journal of developmental disabilities · 2026Article
- A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1Nature communications · 2026Article
- EEG hyperscanning in intellectual disability: a scoping review with implications for cognitive stimulation therapy.Frontiers in neuroergonomics · 2026Review
- Adults with Down syndrome display altered entrainment of occipital cortical neurons.Brain communications · 2026Article
- Synaptic inhibitory dynamics drive benzodiazepine response in pediatric status epilepticus.Epilepsia · 2025Article
- Neuronal oscillations in cognition: Down syndrome as a model of mouse to human translation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Adults with down syndrome exhibit altered somatosensory cortical inhibition.NeuroImage. Clinical · 2025Article
- EEG in Down Syndrome-A Review and Insights into Potential Neural Mechanisms.Brain sciences · 2024Review
- Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome.Neurobiology of disease · 2023Article
- Toward the Identification of Neurophysiological Biomarkers for Alzheimer's Disease in Down Syndrome: A Potential Role for Cross-Frequency Phase-Amplitude Coupling Analysis.Aging and disease · 2023Review
- Evaluating Verbal Fluency Outcome Measures in Children With Down Syndrome.American journal on intellectual and developmental disabilities · 2022Article
- Brain signal complexity in adults with Down syndrome: Potential application in the detection of mild cognitive impairment.Frontiers in aging neuroscience · 2022Article
- Language and executive functioning in young adults with Down syndrome.Journal of intellectual disability research : JIDR · 2022Article
- Cognitive training in adults with intellectual disability: pilot study applying a cognitive tele-rehabilitation program.International journal of developmental disabilities · 2022Article
- Comparison of resting-state EEG between adults with Down syndrome and typically developing controls.Journal of neurodevelopmental disorders · 2021Article
- Differences in visually induced MEG oscillations reflect differences in deep cortical layer activity.Communications biology · 2020Article
- Cortical beta oscillations reflect the contextual gating of visual action feedback.NeuroImage · 2020Article
- Prefrontal-hippocampal functional connectivity encodes recognition memory and is impaired in intellectual disability.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Individuals with Down syndrome (DS) show high inter-subject variability in cognitive ability and have an ultra-high risk of developing dementia (90% lifetime prevalence). Elucidating factors underlying variability in cognitive function can inform us about intellectual disability (ID) and may improve our understanding of factors associated with later cognitive decline. Increased neuronal inhibition has been posited to contribute to ID in DS. Combining electroencephalography (EEG) with dynamic causal modeling (DCM) provides a non-invasive method for investigating excitatory/inhibitory mechanisms. Resting-state EEG recordings were obtained from 36 adults with DS with no evidence of cognitive decline. Theta-alpha activity (4-13 Hz) was characterized in relation to general cognitive ability (raw Kaufmann's Brief Intelligence Test second Edition (KBIT-2) score). Higher KBIT-2 was associated with higher frontal alpha peak amplitude and higher theta-alpha band power across distributed regions. Modeling this association with DCM revealed intrinsic self-inhibition was the key network parameter underlying observed differences in 4-13 Hz power in relation to KBIT-2 and age. In particular, intrinsic self-inhibition in right V1 was negatively correlated with KBIT-2. Results suggest intrinsic self-inhibition within the alpha network is associated with individual differences in cognitive ability in adults with DS, and may provide a potential therapeutic target for cognitive enhancement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.