ArticleCerebral cortex (New York, N.Y. : 1991)2019
Association Between Earliest Amyloid Uptake and Functional Connectivity in Cognitively Unimpaired Elderly.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- A Systematic Review of the Association between Amyloid-β and τ Pathology with Functional Connectivity Alterations in the Alzheimer Dementia Spectrum Utilizing PET Scan and rsfMRI.Dementia and geriatric cognitive disorders extraPooled it
- Network-specific metabolic cost of functional connectivity in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Network-level functional connectivity is associated with longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer's disease.Research square · 2026Article
- Integrating Time and Frequency Domain Features of fMRI Time Series for Alzheimer's Disease Classification Using Graph Neural Networks.Interdisciplinary sciences, computational life sciences · 2026Article
- Pretangle tau pathology accrual in the default mode network during the progression of Alzheimer's disease.Molecular neurodegeneration advances · 2026Article
- Integrating individualized connectome with amyloid pathology improves predictive modeling of future cognitive decline.Communications medicine · 2025Article
- Altered Functional Connectivity and Amyloid Deposition in Posttraumatic Stress Disorder-Associated Cognitive Impairment.AJNR. American journal of neuroradiology · 2025Article
- Anterior-temporal network hyperconnectivity is key to Alzheimer's disease: from ageing to dementia.Brain : a journal of neurology · 2025Article
- Multimodal neuroimaging insights into the neurobiology of healthy aging across the lifespan.European journal of nuclear medicine and molecular imaging · 2025Article
- Autonomic dysfunction in neurodegenerative disease.Nature reviews. Neuroscience · 2025Review
- Dynamic Functional Network Connectivity Pattern of the Amygdalohippocampal Complex in Individuals With Subjective Cognitive Decline.Human brain mapping · 2025Article
- Association of Plasma Biomarkers of Alzheimer Disease and Neurodegeneration With Longitudinal Intra-Network Functional Brain Connectivity.Neurology · 2025Article
- A whole-brain functional connectivity model of Alzheimer's disease pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Biological mechanisms of resilience to tau pathology in Alzheimer's disease.Alzheimer's research & therapy · 2024Article
- The Azalea Hypothesis of Alzheimer Disease: A Functional Iron Deficiency Promotes Neurodegeneration.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Age differences in BOLD modulation to task difficulty as a function of amyloid burden.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Linking the neural signature of response time variability to Alzheimer's disease pathology and cognitive functioning.Network neuroscience (Cambridge, Mass.) · 2024Article
- Disruption in functional networks mediated tau spreading in Alzheimer's disease.Brain communications · 2024Article
- Resting-state functional connectivity changes in older adults with sleep disturbance and the role of amyloid burden.Molecular psychiatry · 2023Article
- Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in cognitive performance have been noted in nondemented subjects with elevated accumulation of amyloid-β (Aβ) fibrils. However, it is not yet understood whether brain function is already influenced by Aβ deposition during the very earliest stages of the disease. We therefore investigated associations between [18F]Flutemetamol PET, resting-state functional connectivity, gray and white matter structure and cognitive performance in 133 cognitively normal elderly that exhibited normal global Aβ PET levels. [18F]Flutemetamol uptake in regions known to accumulate Aβ fibrils early in preclinical AD (i.e., mainly certain parts of the default-mode network) was positively associated with dynamic but not static functional connectivity (r = 0.77). Dynamic functional connectivity was further related to better cognitive performance (r = 0.21-0.72). No significant associations were found for Aβ uptake with gray matter volume or white matter diffusivity. The findings demonstrate that the earliest accumulation of Aβ fibrils is associated with increased functional connectivity, which occurs before any structural alterations. The enhanced functional connectivity may reflect a compensatory mechanism to maintain high cognitive performance in the presence of increasing amyloid accumulation during the earliest phases of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.