ArticleAging clinical and experimental research2020
Untangling the relationship between fat distribution, nutritional status and Parkinson's disease severity.
Article in Aging clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Implication of nutrition in severity of symptoms and treatments in quality of life in Parkinson's disease: a systematic review.Frontiers in nutrition · 2024Pooled it
- Prevalence of Malnutrition in Patients with Parkinson's Disease: A Systematic Review.Nutrients · 2022Pooled it
- Exploring the impacts of type 2 diabetes and metformin use on Parkinson's disease: Mendelian randomization analysis and a national cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Common features in the gut microbiota of underweight and overweight individuals and patients with Parkinson's disease - a mini-review.Pharmacological reports : PR · 2026Review
- Nutritional status and dynapenia in people living with Parkinson's disease: a cross-sectional study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Changes in Body Composition Before and After Parkinson's Disease Diagnosis.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Prevalence and Risk Factors for Malnutrition in Patients With Parkinson's Disease.Frontiers in neurology · 2020Article
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson's disease (PD) is responsible for significant changes in body composition.
aimsWe aimed to test the association between PD severity and fat distribution patterns, and to investigate the potential modifier effect of nutritional status in this association.
methodsWe enrolled 195 PD subjects consecutively admitted to a university geriatric day hospital. All participants underwent comprehensive clinical evaluation, including assessment of total and regional body composition (dual-energy X-ray absorptiometry, DXA), body mass index, nutritional status (Mini-Nutritional Assessment, MNA), motor disease severity (UPDRS III), comorbidities, and pharmacotherapy.
resultsThe fully adjusted linear regression model showed a negative association between UPDRS III and total body fat in kg and percentage (respectively, B - 0.79; 95% CI - 1.54 to - 0.05 and B - 0.55; 95% CI - 1.04 to - 0.05), percentage android fat (B - 1.07; 95% CI - 1.75 to - 0.39), trunk-leg fat ratio (B - 0.02; 95% CI - 0.04 to - 0.01), trunk-limb fat ratio (B - 0.01; 95% CI - 0.06 to - 0.01) and android-gynoid fat ratio (B - 0.01; 95% CI - 0.03 to - 0.01). After stratification by MNA score, all the parameters of android-like fat distribution resulted negatively associated (p < 0.001 for all) with UPDRS III, but only among subjects with a MNA < 23.5 (risk of malnutrition or malnutrition).
conclusionWe found a negative association between severity of motor impairment and total fat mass in PD, more specific with respect to an android pattern of fat distribution. This association seems to be driven by nutritional status, and is significant only among patients at risk of malnutrition or with overt malnutrition.
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