Evidence map›Paper›PMID 30877563›Full record

ArticleJournal of cardiovascular translational research2019

Intra-aortic Balloon Counterpulsation for High-Risk Percutaneous Coronary Intervention: Defining Coronary Responders.

Natalia Briceno, Kalpa De Silva, Matthew Ryan, Tiffany Patterson, Kevin O'Gallagher, Howard Ellis, Simone Rivolo, Jack Lee, Simon Redwood, Ajay M Shah and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Natalia BricenoSchool of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Excellence and National Institute for Health Research Biomedical Research Centre, St. Thomas' Hospital Campus, King's College London, London, SE1 7EH, UK.
Kalpa De SilvaBristol Heart Institute, University Hospitals Bristol and University of Bristol, Bristol, UK.
Matthew RyanSchool of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Excellence and National Institute for Health Research Biomedical Research Centre, St. Thomas' Hospital Campus, King's College London, London, SE1 7EH, UK.
Tiffany PattersonSchool of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Excellence and National Institute for Health Research Biomedical Research Centre, St. Thomas' Hospital Campus, King's College London, London, SE1 7EH, UK.
Kevin O'GallagherKing's College London British Heart Foundation Centre of Research Excellence, The James Black Centre, 125 Coldharbour Lane, London, UK.
Howard EllisSchool of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Excellence and National Institute for Health Research Biomedical Research Centre, St. Thomas' Hospital Campus, King's College London, London, SE1 7EH, UK.
Simone RivoloDepartment of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Jack LeeDepartment of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Simon RedwoodSchool of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Excellence and National Institute for Health Research Biomedical Research Centre, St. Thomas' Hospital Campus, King's College London, London, SE1 7EH, UK.
Ajay M ShahKing's College London British Heart Foundation Centre of Research Excellence, The James Black Centre, 125 Coldharbour Lane, London, UK.
Michael MarberSchool of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Excellence and National Institute for Health Research Biomedical Research Centre, St. Thomas' Hospital Campus, King's College London, London, SE1 7EH, UK.
Divaka PereraSchool of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Excellence and National Institute for Health Research Biomedical Research Centre, St. Thomas' Hospital Campus, King's College London, London, SE1 7EH, UK. Divaka.Perera@kcl.ac.uk.

Funding

British Heart Foundation CS/16/3/32615Department of Health
6 · The paper itself

Abstract

The effect of intra-aortic balloon counterpulsation (IABC) varies, and it is unknown whether this is due to a heterogeneous coronary physiological response. This study aimed to characterise the coronary and left ventricular (LV) effects of IABC and define responders in terms of their invasive physiology. Twenty-seven patients (LVEF 31 ± 9%) underwent coronary pressure and Doppler flow measurements in the target vessel and acquisition of LV pressure volume loops after IABC supported PCI, with and without IABC assistance. Through coronary wave intensity analysis, perfusion efficiency (PE) was calculated as the proportion of total wave energy comprised of accelerating waves, with responders defined as those with an increase in PE with IABC. The myocardial supply/demand ratio was defined as the ratio between coronary flow and LV pressure volume area (PVA). Responders (44.4%) were more likely to have undergone complex PCI (p = 0.03) with a higher pre-PCI disease burden (p = 0.02) and had lower unassisted mean arterial (87.4 ± 11.0 vs. 77.8 ± 11.6 mmHg, p = 0.04) and distal coronary pressures (88.0 ± 11.0 vs. 71.6 ± 12.4 mmHg, p < 0.001). There was no effect overall of IABC on the myocardial supply/demand ratio (p = 0.34). IABC has minimal effect on demand, but there is marked heterogeneity in the coronary response to IABC, with the greatest response observed in those patients with the most disordered autoregulation.

Indexed as

Coronary CirculationHemodynamicsIntra-Aortic Balloon PumpingPercutaneous Coronary InterventionVentricular Function, LeftAgedCoronary Artery DiseaseEnglandFemaleHumansMaleMiddle AgedPatient SelectionRecovery of FunctionStroke VolumeTime FactorsCoronary perfusion efficiencyCoronary respondersIntra-aortic balloon counterpulsationMyocardial supply/demand ratioWave intensity analysis

Identifiers

PMID30877563
PMCPMC6708049

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.