ArticleAnnals of surgical oncology2019
Association of Perioperative Transfusion with Recurrence and Survival After Resection of Distal Cholangiocarcinoma: A 10-Institution Study from the US Extrahepatic Biliary Malignancy Consortium.
Article in Annals of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of Laparoscopic Surgery with Improved Perioperative and Survival Outcomes in Patients with Resectable Intrahepatic Cholangiocarcinoma: A Systematic Review and Meta-Analysis from Propensity-Score Matched Studies.Annals of surgical oncology · 2023Pooled it
- Red blood cell transfusions and the survival in patients with cancer undergoing curative surgery: a systematic review and meta-analysis.Surgery today · 2021Pooled it
- Outcome of resectable distal cholangiocarcinoma in a single-centre Western patient cohort: comparison of the 7th and 8th edition of the UICC/AJCC TNM classification.Acta oncologica (Stockholm, Sweden) · 2026Article
- Perioperative red blood cell transfusion in gallbladder cancer surgery: Trends and determinants from nationwide data.Annals of hepato-biliary-pancreatic surgery · 2025Article
- Oncologic Outcomes of Intraoperative Autologous Blood Transfusion for Major Oncologic Resection.Annals of surgical oncology · 2025Article
- Laparoscopic versus robotic pancreaticoduodenectomy for distal cholangiocarcinoma after learning curves of surgeons: a multicenter propensity score-matched study.Hepatobiliary surgery and nutrition · 2025Article
- Comparison of laparoscopic and open pancreaticoduodenectomy for distal cholangiocarcinoma and impact factors on textbook outcome.Surgical endoscopy · 2025Article
- Clinical significances of liver fibrotic markers in patients with cholangiocarcinoma after radical resections.Turkish journal of surgery · 2024Article
- The additive effects of anaemia and transfusion on long-term survival after coronary artery bypass surgery.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024Article
- Time to surgery is not an oncological risk factor in patients with cholangiocarcinoma undergoing curative-intent liver surgery.Scientific reports · 2024Article
- General Anesthetics in CAncer REsection Surgery (GA-CARES) randomized multicenter trial of propofol vs volatile inhalational anesthesia: protocol description.Perioperative medicine (London, England) · 2023Article
- Robotic versus open pancreaticoduodenectomy for distal cholangiocarcinoma: a multicenter propensity score-matched study.Surgical endoscopy · 2022Article
- Double purse-string telescoped pancreaticogastrostomy is not superior in preventing pancreatic fistula development in high-risk anastomosis: a 6-year single-center case-control study.Langenbeck's archives of surgery · 2022Article
- Comparison of laparoscopic and open pancreaticoduodenectomy for the treatment of distal cholangiocarcinoma: A propensity score matching analysis.Frontiers in oncology · 2022Article
- Evaluation of Red Blood Cell Transfusion Practice and Knowledge Among Cancer Surgeons.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Observational
- Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection.BMC gastroenterology · 2020Article
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Authors and funding
20 authors.
Funding
Abstract
backgroundPerioperative allogeneic blood transfusion is associated with poor oncologic outcomes in multiple malignancies. The effect of blood transfusion on recurrence and survival in distal cholangiocarcinoma (DCC) is not known.
methodsAll patients with DCC who underwent curative-intent pancreaticoduodenectomy at 10 institutions from 2000 to 2015 were included. Primary outcomes were recurrence-free (RFS) and overall survival (OS).
resultsAmong 314 patients with DCC, 191 (61%) underwent curative-intent pancreaticoduodenectomy. Fifty-three patients (28%) received perioperative blood transfusions, with a median of 2 units. There were no differences in baseline demographics or operative data between transfusion and no-transfusion groups. Compared with no-transfusion, patients who received a transfusion were more likely to have (+) margins (28 vs 14%; p = 0.034) and major complications (46 vs 16%; p < 0.001). Transfusion was associated with worse median RFS (19 vs 32 months; p = 0.006) and OS (15 vs 29 months; p = 0.003), which persisted on multivariable (MV) analysis for both RFS [hazard ratio (HR) 1.8; 95% confidence interval (CI) 1.1-3.0; p = 0.031] and OS (HR 1.9; 95% CI 1.1-3.3; p = 0.018), after controlling for portal vein resection, estimated blood loss (EBL), grade, lymphovascular invasion (LVI), and major complications. Similarly, transfusion of ≥ 2 pRBCs was associated with lower RFS (17 vs 32 months; p < 0.001) and OS (14 vs 29 months; p < 0.001), which again persisted on MV analysis for both RFS (HR 2.6; 95% CI 1.4-4.5; p = 0.001) and OS (HR 4.0; 95% CI 2.2-7.5; p < 0.001). The RFS and OS of patients transfused 1 unit was comparable to patients who were not transfused.
conclusionPerioperative blood transfusion is associated with decreased RFS and OS after resection for distal cholangiocarcinoma, after accounting for known adverse pathologic factors. Volume of transfusion seems to exert an independent effect, as 1 unit was not associated with the same adverse effects as ≥ 2 units.
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