ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2019
Prevalence of fosfomycin resistance among ESBL-producing Escherichia coli isolates in the community, Switzerland.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Screening and molecular characterization of plasmid-mediated fosfomycin resistance in Enterobacterales.Molecular biology reports · 2026Article
- Emergence of Fosfomycin Resistance Among ESBL-ProducingHealth science reports · 2026Article
- Article
- Evaluation of in-feed supplementation of formic acid and thymol as non-antibiotic growth promoters and assessing their effect on antimicrobial resistant E.coli isolated in Turkey.Veterinary research communications · 2024Article
- Bacteriological and molecular study of fosfomycin resistance in uropathogenic Escherichia coli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Fosfomycin susceptibility testing and resistance mechanisms in Enterobacterales in South Africa.African journal of laboratory medicine · 2024Article
- High incidence of fosfomycin-resistant uropathogenic E. coli among children.BMC infectious diseases · 2023Article
- Fosfomycin resistance mechanisms inFrontiers in cellular and infection microbiology · 2023Review
- Prevalence of Fosfomycin Resistance Among Enterobacterales Isolates in A Tertiary Care Hospital from Turkey.Infectious diseases & clinical microbiology · 2022Article
- Emergence of Fosfomycin Resistance by Plasmid-MediatedAntibiotics (Basel, Switzerland) · 2022Article
- Extended-spectrum β-lactamase-producing and carbapenem-resistant Enterobacterales bloodstream infection after solid organ transplantation: Recent trends in epidemiology and therapeutic approaches.Transplant infectious disease : an official journal of the Transplantation Society · 2022Review
- Selective Culture Medium for Screening of Fosfomycin Resistance inJournal of clinical microbiology · 2022Article
- Fosfomycin resistance in community-acquired urinary pathogens from Western Cape, South Africa.Southern African journal of infectious diseases · 2022Article
- Mobile fosfomycin resistance genes in Enterobacteriaceae-An increasing threat.MicrobiologyOpen · 2020Review
- Review
- High Colonization Rate and Heterogeneity of ESBL- and Carbapenemase-ProducingMicroorganisms · 2020Article
- Characterization of FosL1, a Plasmid-Encoded Fosfomycin Resistance Protein Identified in Escherichia coli.Antimicrobial agents and chemotherapy · 2020Article
- Oral Fosfomycin Efficacy with Variable Urinary Exposures following Single and Multiple Doses againstAntimicrobial agents and chemotherapy · 2020Article
- Identification of FosA8, a Plasmid-Encoded Fosfomycin Resistance Determinant from Escherichia coli, and Its Origin in Leclercia adecarboxylata.Antimicrobial agents and chemotherapy · 2019Article
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5 authors.
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Abstract
Our aim was to evaluate the prevalence of fosfomycin-resistant strains among ESBL-producing Escherichia coli isolates recovered from community patients in Switzerland. A total of 1225 ESBL-producing E. coli isolates were collected between 2012 and 2013 from a private and community laboratory. Fosfomycin resistance was assessed by using the novel rapid fosfomycin/E. coli NP test and agar dilution method. Resistant isolates were further investigated for acquired resistance genes fosA1-7 by PCR and sequencing. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) were performed to evaluate the clonal relationship among fosA3-carrying isolates. Out of the 1225 ESBL-producing E. coli isolates analyzed in this study, 1208 were fosfomycin susceptible while 17 were fosfomycin resistant. No discrepancy was observed between the rapid fosfomycin/E. coli NP test and the agar dilution method taken as the gold standard. Five out of the 17 resistant isolates carried a fosA-like gene. No clonal relationship was observed among those isolates. Here, the prevalence of fosfomycin resistance among ESBL-producing E. coli isolates in the community is reported for the first time in Switzerland, being ca. 1.4%. Among the five isolates carrying a fosA gene, four encoded the FosA3 enzyme, being the most prevalent fosfomycin-resistant determinant. An excellent correlation was observed between minimum inhibitory concentration-based susceptibility categorization and results of the rapid fosfomycin/E. coli NP test, further indicating the excellent sensitivity and specificity of this recently developed rapid test whose results are obtained in less than 2 h.
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